Chemical Mixtures and Combined Chemical and Nonchemical Stressors

Exposure, Toxicity, Analysis, and Risk

  • Cynthia V. Rider
  • Jane Ellen Simmons

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Cynthia V. Rider, Jane Ellen Simmons
    Pages 1-12
  3. Combined Exposures

    1. Front Matter
      Pages 13-13
    2. L. Blair Paulik, Kim A. Anderson
      Pages 37-80
    3. Dimosthenis A. Sarigiannis, Spyros P. Karakitsios
      Pages 81-125
  4. Prioritizing Mixtures for Study

  5. Toxicology

    1. Front Matter
      Pages 203-203
    2. Gregg E. Dinse, David M. Umbach
      Pages 205-234
    3. Cynthia V. Rider, Gregg E. Dinse, David M. Umbach, Jane Ellen Simmons, Richard C. Hertzberg
      Pages 235-270
    4. Jane Ellen Simmons, Ingvar Eide, Glenn Rice, Paul Feder
      Pages 335-366
  6. Chemical Mixtures Risk Assessment

    1. Front Matter
      Pages 367-367
    2. Richard C. Hertzberg, M. Moiz Mumtaz
      Pages 369-419
    3. Glenn E. Rice, Ingvar Eide, Paul I. Feder, Chris Gennings
      Pages 421-463
  7. Nonchemical Stressors

    1. Front Matter
      Pages 465-465
    2. Cynthia V. Rider, Thais Morata, MaryJane K. Selgrade, Kenneth Sexton
      Pages 467-492
    3. Jane E. Clougherty, Jonathan I. Levy
      Pages 493-514
  8. Back Matter
    Pages 545-556

About this book


Exposure to multiple chemical and nonchemical stressors is the rule, not the exception. Nevertheless, it continues to be a significant challenge in toxicology and risk assessment to thoroughly take mixtures into account. In this book, both basic and advanced concepts for considering mixtures are discussed, from initial-exposure characterization through the evaluation of risk associated with combined exposures. Several chapters also examine the adoption of promising tools from other disciplines. Looking beyond chemical mixtures, the discussion also addresses incorporating nonchemical stressors into toxicity studies and cumulative-risk assessments.

This “excellent” volume—as described by Linda S. Birnbaum, Director of the National Institute of Environmental Health Sciences and the National Toxicology Program, in her foreword to the book—forms “a comprehensive picture of the current state of mixtures science.” With contributions from a host of established experts, Chemical Mixtures and Combined Chemical and Nonchemical Stressors: Exposure, Toxicity, Analysis, and Risk is an essential text for mixtures researchers in the fields of toxicology, epidemiology, exposure science, risk assessment, and statistics. Both seasoned mixtures researchers and those new to the field will appreciate the clear explanations of mixtures concepts as well as the comprehensive presentation of available tools for predicting mixture effects and estimating risk from combined exposures. This volume also serves as a useful reference book for students. 


Chemical interaction Combined exposures Cumulative toxicology Mixture model Non-chemical stressor Risk assessment

Editors and affiliations

  • Cynthia V. Rider
    • 1
  • Jane Ellen Simmons
    • 2
  1. 1.National Toxicology ProgramNational Institute of Environmental, Health SciencesResearch Triangle ParkUSA
  2. 2.National Health and Environmental Effects Research LaboratoryOffice of Research and Development, U.S. Environmental Protection AgencyResearch Triangle ParkUSA

Bibliographic information

Industry Sectors
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Pharmacology & Toxicology
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