Isolation and Molecular Characterization of Circulating Tumor Cells

  • Mark Jesus M. Magbanua
  • John W. Park

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 994)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Ludmilla Thomé Domingos Chinen, Emne Ali Abdallah, Alexcia Camila Braun, Bianca de Cássia Troncarelli de Campos Parra Flores, Marcelo Corassa, Solange Moraes Sanches et al.
    Pages 1-41
  3. Anna S. Zamay, Galina S. Zamay, Olga S. Kolovskaya, Tatiana N. Zamay, Maxim V. Berezovski
    Pages 67-81
  4. Carolina Reduzzi, Rosita Motta, Giulia Bertolini, Patrizia Miodini, Antonia Martinetti, Elisa Sottotetti et al.
    Pages 83-103
  5. Cyril Catelain, Emma Pailler, Marianne Oulhen, Vincent Faugeroux, Anne-Laure Pommier, Françoise Farace
    Pages 169-179
  6. Rita Lampignano, Helen Schneck, Martin Neumann, Tanja Fehm, Hans Neubauer
    Pages 181-203
  7. Stefan Werner, Arnulf Stenzl, Klaus Pantel, Tilman Todenhöfer
    Pages 205-228
  8. Tomoyuki Okumura, Tetsuji Yamaguchi, Toru Watanabe, Takuya Nagata, Yutaka Shimada
    Pages 247-254
  9. Swee Jin Tan, Trifanny Yeo, Sarvesh Abhay Sukhatme, Say Li Kong, Wan-Teck Lim, Chwee Teck Lim
    Pages 255-273
  10. María José Serrano, María Jesús Alvarez-Cubero, Diego De Miguel Pérez, Alba Rodríguez-Martínez, Lucas Gonzalez-Herrera, Inmaculada Robles-Fernandez et al.
    Pages 285-296
  11. Back Matter
    Pages 297-301

About this book


The past decade has seen remarkable progress in elucidating the clinical relevance of circulating tumor cells (CTCs). Evidence from numerous clinical studies has unequivocally demonstrated the importance of CTCs as harbingers of poor outcome. Despite these advances, the molecular nature of CTCs remains elusive. This is in part due to the difficulty in isolating pure CTCs away from blood cells.

Recent advancements in rare-cell technology have provided solutions to the once daunting task of isolating extremely rare CTCs in the blood of cancer patients. This book presents different novel approaches for detection and purification of CTCs. In addition, the readers are introduced to new technologies for molecular profiling of CTCs, including techniques to overcome limitations posed by the paucity of cells and the biomolecules available for downstream molecular analysis.

This book is particularly relevant to scientists and academicians who are interested in the field of CTC research. It provides an overview of the recent technological advances in CTC isolation and profiling. This work also includes discussions on pertinent issues regarding the biology of CTCs, and their potential utility as liquid biopsy for personalized medicine. We hope that this book stimulate further research and help advance our understanding of the molecular biology of CTCs.


Circulating tumor cells Rare-cell technology Expression profiling Genomic DNA profiling Clinical applications of CTCs

Editors and affiliations

  • Mark Jesus M. Magbanua
    • 1
  • John W. Park
    • 2
  1. 1.University of California San FranciscoSan FranciscoUSA
  2. 2.University of California San FranciscoSan FranciscoUSA

Bibliographic information

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