Table of contents

  1. Front Matter
    Pages i-xi
  2. Dong Lin, Xinya Wang, Peter W. Gout, Yuzhuo Wang
    Pages 1-9
  3. Gail P. Risbridger, Mitchell G. Lawrence
    Pages 11-28
  4. Fallon K. Noto, Tseten Yeshi
    Pages 43-57
  5. Danyi Wen, Feifei Zhang, Yuan Long
    Pages 59-69
  6. Alastair H. Davies, Fraser Johnson, Kirsi Ketola, Amina Zoubeidi
    Pages 71-91
  7. Nora M. Navone, Estefania Labanca
    Pages 93-114
  8. Erin L. Stewart, Ming Sound Tsao
    Pages 115-126
  9. Werner J. Struss, Peter C. Black
    Pages 127-140
  10. Xin Dong, Peter W. Gout, Lu Yi, Yinhuai Wang, Yong Xu, Kuo Yang
    Pages 155-176
  11. Hongwei Cheng, Zongwen Liu, Hui Xue, Peter W. Gout, Hong Shan
    Pages 177-192
  12. Dong Lin, Yuzhuo Wang, Peter W. Gout
    Pages 193-200
  13. Back Matter
    Pages 201-204

About this book


This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text. 

Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current status of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field.


PDX cancer models cancer heterogeneity Modeling cancer metastasis Modeling drug resistance PDX and biomarker development

Editors and affiliations

  • Yuzhuo Wang
    • 1
  • Dong Lin
    • 2
  • Peter W. Gout
    • 3
  1. 1.Department of Urologic SciencesUniversity of British ColumbiaVancouverCanada
  2. 2.Department of Experimental TherapeuticsBC Cancer Research CentreVancouverCanada
  3. 3.Living Tumor LaboratoryBC Cancer Agency/Vancouver Prostate CentreVancouverCanada

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Humana Press, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-55824-0
  • Online ISBN 978-3-319-55825-7
  • Series Print ISSN 2197-7852
  • Series Online ISSN 2197-7860
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Oncology & Hematology