© 2017

Molecular Basis for Mitochondrial Signaling

  • Tatiana K. Rostovtseva

Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Mitochondrial Calcium Signaling

    1. Front Matter
      Pages 1-1
    2. Riccardo Filadi, Pierre Theurey, Alice Rossi, Chiara Fedeli, Paola Pizzo
      Pages 3-39
    3. Vanessa Checchetto, Diego De Stefani, Anna Raffaello, Rosario Rizzuto, Ildiko Szabo
      Pages 41-65
  3. The Mitochondrial Permeability Transition Pore: Structure and Function

    1. Front Matter
      Pages 67-67
    2. Elizabeth A. Jonas, George A. Porter Jr., Gisela Beutner, Nelli Mnatsakanyan, Han-A. Park, Nikita Mehta et al.
      Pages 69-105
  4. Mitochondrial Outer Membrane Transport Systems: Structure, Function, and Physiological Implications

    1. Front Matter
      Pages 119-119
    2. Eduardo N. Maldonado, David N. DeHart, John J. Lemasters
      Pages 121-140
    3. Lucie Bergdoll, Michael Grabe, Jeff Abramson
      Pages 141-160
    4. Fabrice Homblé, Hana Kmita, Hayet Saidani, Marc Léonetti
      Pages 161-183
    5. Tatiana K. Rostovtseva, David P. Hoogerheide, Amandine Rovini, Sergey M. Bezrukov
      Pages 185-215
  5. Mitochondria and Cellular Signaling Network

    1. Front Matter
      Pages 251-251
    2. Michele Frison, Anna Katherina Mallach, Emma Kennedy, Michelangelo Campanella
      Pages 285-315
    3. Ma Su Su Aung, Ruth Hartke, Stephen Madamba, Oygul Mirzalieva, Pablo M. Peixoto
      Pages 317-347
    4. Sonia Cortassa, Steven J. Sollott, Miguel A. Aon
      Pages 349-375
  6. Back Matter
    Pages 377-386

About this book


This book covers recent advances in the study of structure, function, and regulation of metabolite, protein and ion translocating channels, and transporters in mitochondria. A wide array of cutting-edge methods are covered, ranging from electrophysiology and cell biology to bioinformatics, as well as structural, systems, and computational biology. At last, the molecular identity of two important channels in the mitochondrial inner membrane, the mitochondrial calcium uniporter and the mitochondrial permeability transition pore have been established. After years of work on the physiology and structure of VDAC channels in the mitochondrial outer membrane, there have been multiple discoveries on VDAC permeation and regulation by cytosolic proteins. Recent breakthroughs in structural studies of the mitochondrial cholesterol translocator reveal a set of novel unexpected features and provide essential clues for defining therapeutic strategies. Molecular Basis for Mitochondrial Signaling covers these and many more recent studies of mitochondria function, their communication with other organelles, and their critical roles in development, aging, and in a plethora of stressful or degenerative events. Authored by leading researchers in the field, this volume will be an indispensable reference resource for graduate students and academics working in related areas of biophysics and cell biology as well as for professionals within industry.


Biophysics of membrane transport Calcium signaling Cellular metabolism Ion channels and transporters Mitochondria and disease Mitochondria in apoptosis Mitochondrial metabolism Proapoptotic proteins

Editors and affiliations

  • Tatiana K. Rostovtseva
    • 1
  1. 1.Section on Molecular TransportEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthBethesdaUSA

Bibliographic information

  • Book Title Molecular Basis for Mitochondrial Signaling
  • Editors Tatiana K. Rostovtseva
  • Series Title Biological and Medical Physics, Biomedical Engineering
  • Series Abbreviated Title Biol., Med. Physics, Biomed. Engineer.
  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Physics and Astronomy Physics and Astronomy (R0)
  • Hardcover ISBN 978-3-319-55537-9
  • Softcover ISBN 978-3-319-85688-9
  • eBook ISBN 978-3-319-55539-3
  • Series ISSN 1618-7210
  • Series E-ISSN 2197-5647
  • Edition Number 1
  • Number of Pages XIV, 386
  • Number of Illustrations 7 b/w illustrations, 54 illustrations in colour
  • Topics Biological and Medical Physics, Biophysics
    Cell Cycle Analysis
  • Buy this book on publisher's site
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