© 2018

Irreversible Electroporation in Clinical Practice

  • Martijn R. Meijerink
  • Hester J. Scheffer
  • Govindarajan Narayanan

Table of contents

  1. Front Matter
    Pages i-vi
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Hester J. Scheffer
      Pages 3-11
    3. Andrea Rolong, Rafael V. Davalos, Boris Rubinsky
      Pages 13-37
  3. Preclinical Research

    1. Front Matter
      Pages 39-39
    2. Daniel C. Sweeney, Robert E. Neal II, Rafael V. Davalos
      Pages 41-66
    3. Jantien A. Vogel, Laurien G. P. H. Vroomen, Govindarajan Srimathveeravalli
      Pages 81-94
  4. Technique, Tips and Tricks

    1. Front Matter
      Pages 95-95
    2. Jenny M. Vieveen, R. Arthur Bouwman
      Pages 97-103
    3. Laurien G. P. H. Vroomen, K. Nielsen, A. H. Ruarus, Hester J. Scheffer
      Pages 105-114
    4. Lukas Philipp Beyer, Philipp Wiggermann
      Pages 115-120
    5. Eran van Veldhuisen, J. A. Vogel, J. H. Klaessens, R. M. Verdaasdonk
      Pages 121-136
  5. Clinical Practice

    1. Front Matter
      Pages 137-137
    2. Karin Nielsen, Hester J. Scheffer, M. Petrousjka van den Tol, Anders Nilsson
      Pages 139-166
    3. Martijn R. Meijerink, Anders Nilsson, Govindarajan Narayanan, Robert Martin
      Pages 167-190
    4. Eva Roos, Laurien G. P. H. Vroomen, Eran van Veldhuisen, Robert-Jan Coelen, Thomas M. van Gulik, Martijn R. Meijerink
      Pages 191-200
    5. Jim Koukounaras, Helen Kavnoudias, Kenneth R. Thomson
      Pages 201-213
    6. Matthijs Scheltema, Jean de la Rosette
      Pages 215-222
    7. Martijn R. Meijerink, Nicole van Grieken, Laurien G. P. H. Vroomen
      Pages 223-238

About this book


This book provides a comprehensive overview of the clinical use of irreversible electroporation (IRE) – better known by its commercial name, NanoKnife – which is one of the most exciting new needle-guided cancer treatments. The coverage includes the history of IRE, general technique, preclinical research, applications in clinical practice and early clinical results, and future perspectives. Contraindications, treatment planning, potential complications, follow-up imaging, and other practical aspects are fully discussed, with highlighting of useful tips and tricks.

Through the delivery of short but highly intense electrical pulses, IRE results in tumor cell membrane permeabilization, causing cells to go into apoptosis. The minimally invasive nature of IRE, combined with the prospect of completely eradicating tumors while preserving delicate structures in the ablation zone, makes IRE the object of worldwide clinical research. This book will be of value for practitioners and trainees in interventional and diagnostic radiology, surgery, medical oncology, HPB and gastroenterology, urology, and radiation oncology.


Irreversible electroporation Tumor ablation Image-Guided Cancer Treatment Interventional oncology IRE NanoKnife Needle-guided cancer treatment

Editors and affiliations

  • Martijn R. Meijerink
    • 1
  • Hester J. Scheffer
    • 2
  • Govindarajan Narayanan
    • 3
  1. 1.Department of Radiology and Nuclear MedicineVU University AmsterdamAmsterdamThe Netherlands
  2. 2.Department of Radiology and Nuclear MedicineVU University AmsterdamAmsterdamThe Netherlands
  3. 3.Vascular and Interventional RadiologyMiami University Hospital and ClinicsMiamiUSA

About the editors

Martijn Meijerink, MD, PhD is an interventional radiologist with interventional oncology as special field of expertise at the VU University Medical Center (VUmc) in Amsterdam, affiliated with the Cancer Center Amsterdam (CCA) which houses one of the largest academic oncology centers in Europe. He is a renowned expert in the field of interventional oncology procedures, such as radiofrequency ablation, microwave ablation, irreversible electroporation (nanoknife), transarterial bland embolization, chemo- and Y90 radioembolization. As chief of the research center for image-guided tumor ablation in Amsterdam he is continuously searching for ways to improve survival and quality of life of patients with cancer.

Hester Scheffer, MD is a senior-researcher at the VU University Medical Center in Amsterdam and one of the key opinion leaders in the field of irreversible electroporation research. Having conducted extensive translational research she was the first to prove actual cell death in the clinical setting caused by irreversible electroporation. In the preclinical setting, she focuses on electrical field modeling and the thermal component of irreversible electroporation, whereas in the clinical setting she coordinates several large trials on the efficacy of hepatic and pancreatic irreversible electroporation and she is the author of the only issued systematic review on irreversible electroporation. Together with Dr. Meijerink she is the founder of a worldwide network for irreversible electroporation research in the field of interventional oncology.

Bibliographic information

Industry Sectors
Health & Hospitals
Oncology & Hematology