© 2017

Microdomains in the Cardiovascular System

  • Viacheslav Nikolaev
  • Manuela Zaccolo


  • First book comprehensively reviewing signaling microdomains in the cardiovascular system

  • Thoroughly explains important cellular events and mechanisms

  • Highlights the role of microdomains in cardiovascular disease

  • Experts provide insight into successful methodologies and techniques


Part of the Cardiac and Vascular Biology book series (Abbreviated title: Card. vasc. biol., volume 3)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Cyclic Nucleotide Microdomains

    1. Front Matter
      Pages 1-1
    2. Nadja I. Bork, Viacheslav O. Nikolaev
      Pages 3-15
    3. Shailesh R. Agarwal, Rennolds S. Ostrom, Robert D. Harvey
      Pages 17-35
    4. John M. Redden, Kimberly L. Dodge-Kafka, Michael S. Kapiloff
      Pages 37-57
    5. Alessandra Ghigo, Flora Pirozzi, Mingchuan Li, Emilio Hirsch
      Pages 85-95
    6. Ibrahim Bedioune, Pierre Bobin, Jérôme Leroy, Rodolphe Fischmeister, Grégoire Vandecasteele
      Pages 97-116
    7. Lauren Wills, Bracy A. Fertig, George S. Baillie
      Pages 161-173
    8. Lise Román Moltzau, Silja Meier, Kjetil Wessel Andressen, Finn Olav Levy
      Pages 245-271
    9. Brian Leei Lin, David A. Kass, Dong I. Lee
      Pages 273-290
  3. Calcium Microdomains

    1. Front Matter
      Pages 291-291
    2. Alexey V. Glukhov, Anamika Bhargava, Julia Gorelik
      Pages 293-319
    3. Karin P. Hammer, Lars S. Maier
      Pages 321-340
    4. A. M. Gómez, T. R. R. Mesquita, J. J. Mercadier, J. L. Álvarez, J. P. Benitah
      Pages 361-386

About this book


The book comprehensively presents new findings in cardiovascular research related to signaling microdomains in health and disease. Important second messengers such as cAMP, cGMP, calcium and their role in microdomain signaling are discussed. The book offers and explains methodical approaches and technical ways how to successfully analyze microdomain signaling, also in the context of disease. It further provides scientific perspectives and strategies that are based on the concept of signaling within microdomains and that can revolutionize pharmacology and eventually lead to the effective treatment of cardiovascular diseases in future.
This book is written for scientists in cardiovascular research, pharmacology, molecular and cellular biology as well as medical doctors in cardiology, angiology and nephrology. 


microdomain signaling cardiovascular cardiomyocyte second messenger

Editors and affiliations

  • Viacheslav Nikolaev
    • 1
  • Manuela Zaccolo
    • 2
  1. 1.Institute of Experimental Cardiovascular ResearchUniversity Medical CenterHamburg-EppendorfGermany
  2. 2.Department of Physiology, Anatomy and GeneticsUniversity of OxfordOxfordUK

About the editors

Prof. Viacheslav Nikolaev, PhD is the Director of the Institute of Experimental Cardiovascular Research at the University Medical Center Hamburg-Eppendorf, Germany. He is also a member of the German Center for Cardiovascular Research (DZHK). His main interest is live-cell imaging of cardiac cAMP and cGMP microdomains and their role in heart failure.


Prof. Manuela Zaccolo, MD is the Director of the Burdon Sanderson Cardiac Science Centre and works in the Department of Physiology, Anatomy and Genetics at the University of Oxford. She is interested in the regulatory principles by which intracellular signalling networks achieve the plasticity and context-sensitivity necessary for a cell to function. A central topic of her research is the role of local regulation of cyclic nucleotide signalling in healthy and diseased hearts.   

Bibliographic information

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