© 2017

Computational Methods for Processing and Analysis of Biological Pathways


Part of the SpringerBriefs in Computer Science book series (BRIEFSCOMPUTER)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Anastasios Bezerianos, Andrei Dragomir, Panos Balomenos
    Pages 1-10
  3. Anastasios Bezerianos, Andrei Dragomir, Panos Balomenos
    Pages 11-46
  4. Anastasios Bezerianos, Andrei Dragomir, Panos Balomenos
    Pages 47-68
  5. Anastasios Bezerianos, Andrei Dragomir, Panos Balomenos
    Pages 69-87

About this book


This work offers a guided walkthrough of one of the most promising research areas in modern life sciences, enabling a deeper understanding of involved concepts and methodologies via an interdisciplinary view, focusing on both well-established approaches and cutting-edge research. Highlighting what pathway analysis can offer to both the experimentalist and the modeler, the text opens with an introduction to a general methodology that outlines common workflows shared by several methods. This is followed by a review of pathway and sub-pathway based approaches for systems pharmacology. The work then presents an overview of pathway analysis methods developed to model the temporal aspects of drug- or disease-induced perturbations and extract relevant dynamic themes. The text concludes by discussing several state-of-the-art methods in pathway analysis, which address the important problem of identifying differentially expressed pathways and sub-pathways.


Bioinformatics Systems Biology Network Biology Pathway Analysis Graph Theory

Authors and affiliations

  1. 1.University of PatrasPatrasGreece
  2. 2.University of HoustonHoustonUSA
  3. 3.University of PatrasPatrasGreece

About the authors

Anastasios Bezerianos is a Professor at the Medical School of Patras University, Greece. He is also a Senior Principal Research Fellow at the Singapore Institute for Neurotechnology (SINAPSE) within the Centre for Life Sciences (CeLS), a Research Professor in the Department of Electrical and Computer Engineering (ECE), and a member of the Faculty of NUS Graduate School (NGS) for Integrative Sciences and Engineering at the National University of Singapore (NUS).

Andrei Dragomir is a Research Assistant Professor at the Department of Biomedical Engineering of the University of Houston, TX, USA.

Panos Balomenos is a PhD Candidate at the Computer Engineering and Informatics Department of the University of Patras, Greece.

Bibliographic information

  • Book Title Computational Methods for Processing and Analysis of Biological Pathways
  • Authors Anastasios Bezerianos
    Andrei Dragomir
    Panos Balomenos
  • Series Title SpringerBriefs in Computer Science
  • Series Abbreviated Title SpringerBriefs Computer Sci.
  • DOI
  • Copyright Information The Author(s) 2017
  • Publisher Name Springer, Cham
  • eBook Packages Computer Science Computer Science (R0)
  • Softcover ISBN 978-3-319-53867-9
  • eBook ISBN 978-3-319-53868-6
  • Series ISSN 2191-5768
  • Series E-ISSN 2191-5776
  • Edition Number 1
  • Number of Pages VIII, 87
  • Number of Illustrations 0 b/w illustrations, 11 illustrations in colour
  • Topics Computational Biology/Bioinformatics
    Systems Biology
  • Buy this book on publisher's site
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