© 2017

Asbestos and Mesothelioma

  • Joseph R. Testa

Part of the Current Cancer Research book series (CUCR)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Joseph R. Testa
    Pages 1-9
  3. Ann G. Wylie
    Pages 11-41
  4. Suresh H. Moolgavkar, Ellen T. Chang, Gabor Mezei, Fionna S. Mowat
    Pages 43-72
  5. Edward A. Emmett, Brigid Cakouros
    Pages 103-130
  6. Elizabeth N. Pavlisko, John M. Carney, Thomas A. Sporn, Victor L. Roggli
    Pages 131-160
  7. Assunta De Rienzo, William G. Richards, Raphael Bueno
    Pages 197-209
  8. V. Courtney Broaddus, Carlo Follo, Dario Barbone
    Pages 237-257
  9. Clementina Mesaros, Liwei Weng, Ian A. Blair
    Pages 259-277
  10. Andrea Wolf, Raja Flores
    Pages 279-294
  11. Charles B. Simone II, Theresa M. Busch, Keith A. Cengel
    Pages 295-311
  12. Anish Thomas, Madhuri Badrinath, Raffit Hassan
    Pages 347-357
  13. William M. Buchholz
    Pages 381-407

About this book


This volume is comprised of a multidisciplinary assessment of the interplay between asbestos and cancer as well as new research about the biology and treatment of malignant mesothelioma.  Chapters on the various types of asbestos and other mineral fibers, epidemiology, history and future of asbestos-related diseases are included.  Other reviews present new information about the role of asbestos-related inflammation and genetic factors, including the role of inherited mutations of BAP1, in mesothelioma causation, as well as recent research about gene signatures, cell signaling, and epigenetic mechanisms in asbestos-related diseases.  Other chapters provide updates of novel disease biomarkers and prevention, mechanistic lesson from genetically engineered mouse and 3-D models of mesothelioma tumorigenesis and therapeutic resistance.  Also included are up-to-date reviews of surgical, molecularly targeted chemotherapeutic, and immunotherapeutic approaches for mesothelioma as well as an overview of legal issues.


Asbestos Cancer Prevention Cell Signaling Epidemiology Gene Signatures Genetics and Epigenetics Inflammation Mesothelioma Mineralogy Surgery and Targeted Therapies Tumor Models

Editors and affiliations

  • Joseph R. Testa
    • 1
  1. 1.Cancer Biology ProgramFox Chase Cancer CenterPhiladelphiaUSA

About the editors

Joseph R. Testa, PhD, FACMG is Senior Member/Professor, Carol and Kenneth E. Weg Chair in Human Genetics, Chief of Laboratory Genetics, and Co-Leader of the Cancer Biology Program at Fox Chase Cancer Center, Philadelphia, PA. His research interests focus on mesothelioma pathogenesis and AKT-related oncogenesis. He has published numerous papers and reviews, and serves on the editorial boards of several journals, including as Senior Editor for Cancer Research. He has received multiple science awards, including the J. Christopher Wagner Medal from the International Mesothelioma Interest Group and the Pioneer Research Award from the Mesothelioma Applied Research Foundation. He is also a Fellow of the American Association for the Advancement of Science.

Bibliographic information

  • Book Title Asbestos and Mesothelioma
  • Editors Joseph R. Testa
  • Series Title Current Cancer Research
  • Series Abbreviated Title Current Cancer Research
  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-53558-6
  • Softcover ISBN 978-3-319-85183-9
  • eBook ISBN 978-3-319-53560-9
  • Series ISSN 2199-2584
  • Series E-ISSN 2199-2592
  • Edition Number 1
  • Number of Pages VIII, 407
  • Number of Illustrations 22 b/w illustrations, 43 illustrations in colour
  • Topics Cancer Research
  • Buy this book on publisher's site
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