Development of In Vitro Maturation for Human Oocytes

Natural and Mild Approaches to Clinical Infertility Treatment

  • Ri-Cheng Chian
  • Geeta Nargund
  • Jack Y. J. Huang

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Ovarian Function

    1. Front Matter
      Pages 1-1
    2. Seido Takae, Nao Suzuki
      Pages 3-35
    3. Han Li, Ri-Cheng Chian
      Pages 37-57
    4. Yoshiharu Morimoto, Shu Hashimoto, Takayuki Yamochi, Hiroya Goto, Ami Amo, Masaya Yamanaka et al.
      Pages 75-91
  3. Natural Cycle IVF and Stimulated Cycle IVF

    1. Front Matter
      Pages 93-93
    2. Sabine Roesner, Thomas Strowitzki
      Pages 95-104
    3. Suchada Mongkolchaipak
      Pages 129-146
    4. A. K. Datta, B. Deval, S. Campbell, G. Nargund
      Pages 147-155
    5. Daniel Bodri
      Pages 157-173
    6. Meera Sridhar Shah, Jack Y.J. Huang
      Pages 185-191
  4. Minimal or Mild Stimulation for IVF

    1. Front Matter
      Pages 193-193
    2. A.K. Datta, S. Campbell, G. Nargund
      Pages 195-209
    3. M. J. Pelinck, A. E. P. Cantineau, J. van Echten-Arends
      Pages 211-226
    4. Alberto Revelli, Simona Casano, Chiara Benedetto
      Pages 249-255
    5. William L. Ledger, Nur Atiqah Hairudin, Chan Soke Yee Sara
      Pages 261-265
    6. Grace Wing Shan Kong, Jin Huang, Tin Chiu Li
      Pages 297-305
  5. Development of In Vitro Maturation

    1. Front Matter
      Pages 307-307
    2. Ri-Cheng Chian
      Pages 309-316
    3. Aisaku Fukuda
      Pages 329-336
    4. Ri-Cheng Chian, Zhi-Yong Yang
      Pages 337-350
  6. Back Matter
    Pages 367-376

About this book


An ideal reference for infertility specialists and reproductive endocrinologists alike, this comprehensive text discusses current natural and mild approaches to in vitro fertilization (IVF) and the development of in vitro maturation (IVM) as a clinical treatment. It is divided thematically into four sections. Part I presents the basic science of ovarian endocrinology and the mechanism of oocyte maturation, including follicular development and the importance of mitochondrial changes. The differences between natural cycle IVF and stimulated IVF are presented in part II, including the standard ovarian stimulation protocols and their outcomes and the etiology, prevention and management of ovarian hyperstimulation syndrome (OHSS). Minimal and mild stimulation for IVF is discussed in part III, including mild stimulation protocols for oncofertility patients and the new minimally invasive INVO procedure. In vitro maturation as a clinical treatment is the subject of part IV, discussing the methodology of immature oocyte retrieval as well as other laboratory aspects and congenital and obstetrical outcomes of babies born from IVM.

Combining expertise from thought leaders around the world, Development of In Vitro Maturation for Human Oocytes will be a go-to resource for infertility researchers and practitioners and reproductive endocrinologists working with infertile couples looking for safer and more cost-effective options for treatment.


Assisted reproductive technology Clomiphene citrate Follicular development GnRH agonist triggering In vitro fertilization In vitro maturation Mild stimulation protocols Minimal stimulation IVF Natural cycle IVF Oocyte maturation Oocyte meiotic resumption Ovarian endocrinology Ovarian hyperstimulation syndrome Ovarian stimulation Single embryo transfer Spontaneous LH surge Stimulated cycle IVF

Editors and affiliations

  • Ri-Cheng Chian
    • 1
  • Geeta Nargund
    • 2
  • Jack Y. J. Huang
    • 3
  1. 1.McGill UniversityLongueuilCanada
  2. 2.St. George's HospitalLondonUnited Kingdom
  3. 3.Stanford UniversityPalo AltoUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-53452-7
  • Online ISBN 978-3-319-53454-1
  • Buy this book on publisher's site
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