© 2017

Male Hypogonadism

Basic, Clinical and Therapeutic Principles

  • Stephen J. Winters
  • Ilpo T. Huhtaniemi

Part of the Contemporary Endocrinology book series (COE)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Joseph P. Moore Jr., Stephen J. Winters
    Pages 1-24
  3. Peter J. O’Shaughnessy
    Pages 25-47
  4. Haiqi Chen, Dolores Mruk, Xiang Xiao, C. Yan Cheng
    Pages 49-72
  5. Sasha Howard, Leo Dunkel
    Pages 73-93
  6. Ravikumar Balasubramanian, William F. Crowley Jr.
    Pages 95-126
  7. Nike M. M. L. Stikkelbroeck, Hedi L. Claahsen-van der Grinten
    Pages 153-167
  8. Rosario Pivonello, Ciro Salzano, Mariano Galdiero, Annamaria Colao
    Pages 169-186
  9. John K. Amory, William J. Bremner
    Pages 187-196
  10. Peter A. Lee, Christopher P. Houk, Jorma Toppari
    Pages 197-217
  11. Samuel M. Kim, Swaytha Yalamanchi, Adrian S. Dobs
    Pages 219-234
  12. Rod T. Mitchell, Jan-Bernd Stukenborg, Kirsi Jahnukainen
    Pages 235-256
  13. Richard M. Sharpe
    Pages 281-304
  14. Peter Y. Liu, Paul Takahashi, Johannes D. Veldhuis
    Pages 325-347
  15. Giulia Rastrelli, Frederick C. W. Wu
    Pages 349-366
  16. Jonas Čeponis, Ronald S. Swerdloff, Christina Wang
    Pages 367-397
  17. Wenyi Zhang, Moizza Shabbir, Peter Y. Liu
    Pages 399-422

About this book


Now in a revised second edition, this comprehensive text covers all aspects of male hypogonadism from the basic science to clinical management, comprehensively explaining and applying new insights to the treatment of hypogonadal men. Chapters covering neuroendocrine control of testicular function, Leydig cell function, spermatogenesis, and normal and delayed puberty open the book. The focus then turns to the pathophysiology and treatment of hypogonadism and other forms of testicular dysfunction, such as Klinefelter syndrome, cryptorchidism, and disorders of the pituitary, as well as reproductive and endocrine consequences of cancer treatment, environmental factors, obesity and aging. Next are chapters that describe the available options for androgen replacement therapy, and the outcomes when men with hypogonadism of various causes are treated with testosterone, as well as a chapter devoted to current approaches to stimulating spermatogenesis in gonadotropin-deficient men. 


Highly practical and updated with the latest available data, this second edition of Male Hypogonadism: Basic, Clinical and Therapeutic Principles cogently presents a large body of scientific information on male reproductive endocrinology to provide a thorough understanding of the pathophysiology, clinical characteristics, and treatments for disorders that adversely affect testicular function.


Aging-related hypoandrogenemia Androgen replacement therapy Congenital hypogonadotropic hypogonadism Cryptorchidism Delayed puberty Gonadotropin deficiency Klinefelter's syndrome Leydig cell function Male hypogonadism Neuroendocrine control Normal puberty Sex hormone-binding globulin Spermatogenesis Spermiogenesis Testicular dysfunction Testosterone

Editors and affiliations

  • Stephen J. Winters
    • 1
  • Ilpo T. Huhtaniemi
    • 2
  1. 1.Department of Medicine, Endocrinology, DUniversity of Louisville Health SciencesLouisvilleUSA
  2. 2.Department of Surgery and CancerImperial College LondonLondonUnited Kingdom

About the editors

Stephen J. Winters, MD, Professor of Medicine, Chief, Division of Endocrinology, Metabolism and Diabetes, University of Louisville, Louisville, KY, USA

Ilpo Huhtaniemi, MD, PhD, Professor Emeritus of Reproductive Endocrinology, Institute of Reproductive and Developmental Biology, Department of Surgery & Cancer, Imperial College London, Hammermith Campus, London, UK

Bibliographic information

  • Book Title Male Hypogonadism
  • Book Subtitle Basic, Clinical and Therapeutic Principles
  • Editors Stephen J. Winters
    Ilpo T. Huhtaniemi
  • Series Title Contemporary Endocrinology
  • Series Abbreviated Title Contemporary Endocrinology
  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Humana Press, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-53296-7
  • Softcover ISBN 978-3-319-85119-8
  • eBook ISBN 978-3-319-53298-1
  • Series ISSN 2523-3785
  • Series E-ISSN 2523-3793
  • Edition Number 2
  • Number of Pages XIV, 446
  • Number of Illustrations 48 b/w illustrations, 42 illustrations in colour
  • Topics Endocrinology
    Reproductive Medicine
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology