© 2017

Canine and Feline Dementia

Molecular Basis, Diagnostics and Therapy

  • Gary Landsberg
  • Aladár Maďari
  • Norbert Žilka

Table of contents

  1. Front Matter
    Pages i-xi
  2. Gary M. Landsberg, Rachel Malamed
    Pages 1-12
  3. Sagi Denenberg, Francois-Xavier Liebel, Jeremy Rose
    Pages 13-58
  4. Aladár Mad’ari, Petr Novak, Norbert Žilka
    Pages 59-68
  5. Joseph A. Araujo, Jessica Baulk, Christina de Rivera
    Pages 69-92
  6. Jeff Nichol, Elizabeth Head
    Pages 93-102
  7. Elizabeth Head, Danièlle Gunn-Moore
    Pages 103-111
  8. Branislav Kovacech, Monika Zilkova, Jozef Hanes, Rostislav Skrabana
    Pages 113-127
  9. Aladár Mad’ari, Jana Farbakova, Norbert Žilka
    Pages 145-154
  10. Back Matter
    Pages 155-159

About this book


The book deeply focuses on the epidemiology, diagnostics, therapy and molecular basis of canine and feline dementia or cognitive dysfunction syndrome. The aim is to provide a broad overview of the current knowledge on canine and feline dementia. Experiences of clinicians are appropriately linked with current scientific knowledge in a readily comprehensible form. In the first three chapters we describe the clinical pictures of canine and feline dementia, discuss the medical causes of the disease and its phenotypic variability. In the 4th chapter we introduce the dog as an appropriate animal model for human Alzheimer’s disease progression. Then we shed light on the neuropathological hallmarks of canine and feline dementia.  For the first time we touch upon the modern diagnostic approaches based on the neuroproteomic technological progress. Last but not least, we address the current pharmacological and non-pharmacological approaches for therapy and risk and protective factors of feline and canine dementia. The book addresses clinicians, researchers, university teachers and graduate students in veterinary neurology and medicine.


cognitive dysfunction syndrome neuroinflammation Alzheimer’s disease ageing pets veterinary neurology cognitive decline DISHA canine and feline dementia risk and protective factors amyloid plaque

Editors and affiliations

  • Gary Landsberg
    • 1
  • Aladár Maďari
    • 2
  • Norbert Žilka
    • 3
  1. 1.North Toronto Veterinary BehaviourSpecialty ClinicThornhillCanada
  2. 2.Univ of Veterinary Medicine and Pharmacy, Small Animal ClinicKošiceSlovakia
  3. 3.Slovak Academy of SciencesInstitute of NeuroimmunologyBratislavaSlovakia

About the editors

Dr. Gary Landsberg BSc, DVM, DACVB, dip ECAWBM received his DVM from the Ontario Veterinary College in 1976. He is a board certified veterinary behaviourist with specialist credentialing from the American College of Veterinary Behaviorists and the European College of Animal Welfare and Behavioural Medicine. He offers behavior consultation services at the North Toronto Veterinary Behaviour Specialty Clinic in Thornhill, is a consultant for VIN, Vice President of Veterinary Affairs for CanCog Technologies and a member of the Fear Free initiative executive committee. He is co-author of Behavior Problems of the Dog and Cat. Dr. Landsberg received the companion animal behavior award from AAHA in 2000 and the meritorious service award from the Western Veterinary Conference in 2014.

Norbert Zilka is an Associate Professor at the University of Veterinary Medicine and Pharmacy in Kosice, Slovakia. He received his Ph.D. degree in immunology from the Institute of Neuroimmunology, Slovak Academy of Sciences in 2006. He is a founder and the director of the Institute of Neuroimmunology, n.o. and vice-chairperson of Slovak Society forNeuroscience. This year, he has been awarded the Doctor of Science (DSc) degree in neuroscience. He has published almost 50 original papers and reviews. His main scientific interest is on pathological hallmarks of Alzheimer’s disease and canine dementia. 

Aladar Madari is an asistent of professor at the University of veterinary medicine and pharmacy in Košice, Slovakia. He works as clinical researcher at Department of Internal Diseases in Small Animal Clinic. He received his Ph.D. degree in the internal medicine of small animals from the Small Animal Clinic, University of Veterinary Medicine and Pharmacy in Košice, Slovakia in 2012. He specialises in neurological disease in geriatric dogs and cats in relation to behavioral changes. He developed CADES (CAnine DEmentia Scale) for quick detection of behavioral changes in senior dogs. He is one of the pioneers of behavioral medicine for small animals in Slovakia. He is a member of several professional and science societies and the Chamber of Veterinary Surgeons in Slovakia. His main professional and scientific interest is on behavioural and neuropathological changes in canine and feline neurodegenerative disorders.

Bibliographic information

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“This book covers canine and feline dementia, spanning topics from clinical signs and differential diagnoses to the use of dogs as a natural model for Alzheimer's disease. … It provides university teachers and scientists with a review of the most up-to-date research on canine and feline dementia while highlighting areas of future research. … This book is a welcome addition to current literature and will serve as a helpful resource for veterinary behaviorists, neurologists, and general practitioners.” (Kelly C. Ballantyne, Doody's Book Reviews, January, 2018)