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Table of contents

  1. Front Matter
    Pages i-v
  2. Bettzy Stephen, Joud Hajjar
    Pages 1-31
  3. Jonathan E. Schoenhals, Tijana Skrepnik, Ugur Selek, Maria A. Cortez, Ailin Li, James W. Welsh
    Pages 53-71
  4. Lucia Masarova, Hagop Kantarjian, Guillermo Garcia-Mannero, Farhad Ravandi, Padmanee Sharma, Naval Daver
    Pages 73-95
  5. Christian Rolfo, Christian Caglevic, Mariacarmela Santarpia, Antonio Araujo, Elisa Giovannetti, Carolina Diaz Gallardo et al.
    Pages 97-125
  6. Peter M. Anderson
    Pages 127-140
  7. Yousra Eleneen, Rivka R. Colen
    Pages 141-153
  8. Noha Abdel-Wahab, Anas Alshawa, Maria E. Suarez-Almazor
    Pages 155-174
  9. Anisha B. Patel, Omar Pacha
    Pages 175-184

About this book

Introduction

In the last decade, immunotherapy has revolutionized the practice of medicine in the field of oncology. This book, Immunotherapy, highlights the immunotherapeutic approaches currently in use and strategies to overcome the associated challenges. As comprehensive knowledge of basic immunology in the context of tumor biology is required to move further along the line of development in translational science, this book provides an overview of the cellular components of the immune system that interact with each other to provide a successful immune response.

Immunotherapy offers promising antitumor activity across multiple cancer types as it does not attack the tumor but primarily revitalizes a suppressed immune system. It is beyond the scope of this book to discuss the immunotherapeutic approaches across the tumor board. However, the book features the role of immune-oncology in acute myeloid leukemia, non-small cell lung cancer, and sarcomas to showcase the recent advances in the management of cancer broadly classified as hematological malignancies, solid tumors, and tumors arising in the connective tissue. The book also discusses alternative formulations and combinatorial approaches to enhance the therapeutic index of these agents.

As immunotherapeutic agents differ significantly from chemotherapeutic agents in response patterns and toxicity profiles, evaluating their safety and efficacy in clinical trials remains a challenge. In this book, we discuss the use of a variety of traditional and new immunotherapy criteria to evaluate response, their inadequacies, and clinical implications. The book also outlines how recent advances in medical imaging technology have the potential to provide high-dimensional data to improve decision support and individualize treatment selection and monitoring. Importantly, the book attempts to increase the awareness to immune related adverse events and the need for aggressive and judicious management of toxicities to improve treatment outcomes in patients on immunotherapy

In short, this book provides a broad understanding of immunotherapy and ways to leverage the immune system to make inroads in the fight against cancer.

Keywords

Immunotherapy Translational cancer immunology Vaccine IL-10 ImmunoOncology

Editors and affiliations

  • Aung Naing
    • 1
  • Joud Hajjar
    • 2
  1. 1.MD Anderson Cancer CenterUniversity of TexasHoustonUSA
  2. 2.Baylor College of Medicine-Texas Children’s HospitalHoustonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-53156-4
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-53155-7
  • Online ISBN 978-3-319-53156-4
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
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