© 2017

Molecular Oncology: Underlying Mechanisms and Translational Advancements

  • Ammad Ahmad Farooqi
  • Muhammad Ismail
  • This book progressively shifts and guides the readers from basic underlying mechanisms to translational approaches to treat cancer.

  • This book will present molecular basis of cancer development, progression and development of resistance against wide ranging therapeutics information

  • Book is appropriately designed for established oncologists, basic and medical students and pharmaceutical industry associated R&D departments

  • Useful for training graduate medical students


Table of contents

  1. Front Matter
    Pages i-x
  2. Rukset Attar, Maria Luisa Gasparri, Talha Abdul Halim, Dana Al Hamwi, Ilknur Ucak, Sundas Fayyaz et al.
    Pages 1-14
  3. Mohadeseh Hasanpourghadi, Ashok Kumar Pandurangan, Mohd. Rais Mustafa
    Pages 15-65
  4. Silvia Novío, María Jesús Núñez-Iglesias, Manuel Freire-Garabal
    Pages 93-107
  5. Aliye Aras Perk, Riffat Batool, Sobia Kanwal, Edyta Pawlak-Adamska, Oskar Nowak, Muhammad Sheeraz Ahmad et al.
    Pages 159-171
  6. Evren Önay Uçar, Murat Pekmez, Nazlı Arda
    Pages 173-192
  7. Maria Luisa Gasparri, Ilary Ruscito, Katayoun Taghavi, Ammad Ahmad Farooqi, Andrea Papadia, Chiara Focaccetti et al.
    Pages 193-204
  8. Steven Pappas, Ke Jin, Brian C. Tse, David T. Tse, Daniel Pelaez, Wensi Tao
    Pages 223-236
  9. Agnieszka Sobczak-Kupiec, Muhammad Javed Iqbal, Muhammad Zahid Qureshi, Qaisar Mansoor, Seyed Mohammad Nabavi, Jelena Purenovic et al.
    Pages 237-245
  10. Minghua Liu, Ge Zhao, Shousong Cao, Yangyang Zhang, Xiaofang Li, Xiukun Lin
    Pages 247-272
  11. Back Matter
    Pages 293-300

About this book


Cancer is a multifaceted and genomically complex disease and data obtained through high throughput technologies has provided near complete resolution of the landscape of how genomic, genetic and epigenetic mutations in cancerous cells effectively influence homeostasis of signaling networks within these cells, between cancerous cells, tumor microenvironment and at the organ level. Increasingly sophisticated information has helped us in developing a better understanding of the underlying mechanisms of cancer, and it is now known that intra-tumor genetic heterogeneity, cellular plasticity, dysregulation of spatio-temporally controlled signaling cascades, and loss of apoptosis are contributory in cancer development, progression and the development of resistance against different therapeutics. It is becoming progressively more understandable that earlier detection of pre-existing or emerging resistance against different therapeutics may prove to be helpful in personalizing the use of targeted cancer therapy. 

Despite the fact that there is a continuously increasing list of books, being guest edited by researchers, books on the subject are often composed of invited reviews without proper sequence and continuity and designed for a particular readership. This book progressively shifts and guides the readers from basic underlying mechanisms to translational approaches to treat cancer.


Adenosine signaling pathways Blood-based cancer detection Cancer therapy Exosomes Microtubule targeting agents Non-coding RNA Oncology Virus caused cancer

Editors and affiliations

  • Ammad Ahmad Farooqi
    • 1
  • Muhammad Ismail
    • 2
  1. 1.Institute of Biomedical and Genetic Engineering (IBGE)IslamabadPakistan
  2. 2.Institute of Biomedical and Genetic Engineering (IBGE)IslamabadPakistan

About the editors

Ammad Ahmad Farooqi is currently a Senior Scientist at the Institute of Biomedical and Genetic Engineering (IBGE), in Islamabad, Pakistan. His area of research is tightly focused on cancer genetics and therapeutics.

Professor Muhammad Ismail has a Ph.D. in Biotechnology and is currently the Director of the Institute of Biomedical and Genetic Engineering (IBGE), in Islamabad. His main focus of research is Cancer Genetics and Therapeutics, Nanomedicine and Pharmacogenomics.

Bibliographic information

  • Book Title Molecular Oncology: Underlying Mechanisms and Translational Advancements
  • Editors Ammad Ahmad Farooqi
    Muhammad Ismail
  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-53081-9
  • Softcover ISBN 978-3-319-85057-3
  • eBook ISBN 978-3-319-53082-6
  • Edition Number 1
  • Number of Pages X, 302
  • Number of Illustrations 3 b/w illustrations, 24 illustrations in colour
  • Topics Cancer Research
  • Buy this book on publisher's site
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