The Molecular Biology of Photorhabdus Bacteria

  • Richard H. ffrench-Constant

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 402)

Table of contents

  1. Front Matter
    Pages i-x
  2. Insecticidal Toxins and Virulence Regulation

  3. Secondary Metabolism and its Regulation

    1. Front Matter
      Pages 53-53
    2. Kenan A. J. Bozhüyük, Qiuqin Zhou, Yvonne Engel, Antje Heinrich, Alexander Pérez, Helge B. Bode
      Pages 55-79
    3. Sophie Brameyer, Ralf Heermann
      Pages 103-119
  4. Insect Immunity

    1. Front Matter
      Pages 121-121
    2. I. Eleftherianos, U. Shokal, S. Yadav, E. Kenney, T. Maldonado
      Pages 123-156
  5. Photorhabdus Asymbiotica and Human Pathogenicity

    1. Front Matter
      Pages 157-157
    2. Alexia Hapeshi, Nick R. Waterfield
      Pages 159-177
    3. John G. Gerrard, Robert P. Stevens
      Pages 179-191
  6. Practical Guides

    1. Front Matter
      Pages 193-193
    2. Jia Yin, Hailong Wang, Ruijuan Li, Vinothkannan Ravichandran, Xiaoying Bian, Aiying Li et al.
      Pages 195-213

About this book


This book provides an essential update on the startling array of novel insecticidal toxins and drugs produced by the fascinating bacterium Photorhabdus. The respective chapters describe everything from the detailed molecular biology of the ‘Toxin complexes’ or Tc’s to the complexity of insect immune response in relation to both the bacterium and its nematode vector. The volume covers both primary (toxin production and regulation) and secondary (natural product synthesis and regulation) metabolism and emphasises the potential use of toxins and drugs in both agriculture and medicine. It also discusses in detail two totally novel quorum sensing mechanisms and the likely role of LuxR solos in sensing the presence of different bacterial hosts. Lastly, the book explores the unique case of P. asymbiotica, which seems to have evolved the ability to infect both insects and humans. This synthesis proves that Photorhabdus truly does offer a ‘gold mine’ for the discovery of novel insecticidal proteins and novel natural products with potential uses in agriculture and medicine alike.


Bacterial signaling Bacterium-nematode complex LuxR solos PaTox PirAB XaxAB Insecticidal drugs Toxin complexes Insecticidal toxins Photorhabdus asymbiotica Photorhabdus luminescens Xenorhabdus

Editors and affiliations

  • Richard H. ffrench-Constant
    • 1
  1. 1.Centre for Ecology and ConservationUniversity of ExeterPenrynUnited Kingdom

Bibliographic information

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