© 2017

Proteomic Methods in Neuropsychiatric Research

  • Paul C. Guest
  • Presents several strategy based chapters, such as those that explain the importance of proteomics in translational medicine and the need for increased proteomic-based platforms in the drug discovery pipeline

  • Describes step-by-step instructions on how to carry out each of the protocols

  • Looks at the future of proteomic platforms including had held devices


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 974)

Also part of the Proteomics, Metabolomics, Interactomics and Systems Biology book sub series (PMISB, volume 974)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Reviews

    1. Front Matter
      Pages 1-1
    2. Renã A. S. Robinson, Bushra Amin, Paul C. Guest
      Pages 21-48
    3. Paul C. Guest, Daniel Martins-de-Souza
      Pages 49-67
    4. Hassan Rahmoune, Daniel Martins-de-Souza, Paul C. Guest
      Pages 69-84
    5. Norma Galicia, Paula Díez, Rosa M. Dégano, Paul C. Guest, Nieves Ibarrola, Manuel Fuentes
      Pages 85-96
    6. Mariana Fioramonte, Paul C. Guest, Daniel Martins-de-Souza
      Pages 115-129
    7. Junfang Chen, Paul C. Guest, Emanuel Schwarz
      Pages 131-138
  3. Protocols

    1. Front Matter
      Pages 139-139
    2. Laurie Stephen, Emanuel Schwarz, Paul C. Guest
      Pages 149-156
    3. Veronica M. Saia-Cereda, Adriano Aquino, Paul C. Guest, Daniel Martins-de-Souza
      Pages 175-182
    4. Sheila Garcia, Licia C. Silva-Costa, Guilherme Reis-de-Oliveira, Paul C. Guest, Paulo A. Baldasso, Juliana S. Cassoli et al.
      Pages 193-203
    5. Guilherme Lanfredi, Guiherme Reis-de-Oliveira, Veronica M. Saia-Cereda, Paul C. Guest, Daniel Martins-de-Souza, Vitor M. Faça
      Pages 205-212
    6. Guilherme Reis-de-Oliveira, Sheila Garcia, Paul C. Guest, Juliana S. Cassoli, Daniel Martins-de-Souza
      Pages 213-218

About this book


Due to continuous technical developments and new insights into the high complexity of neurological diseases, there is an increasing need for the application of proteomic technologies which can yield potential biomarker readouts for improved clinical management as well as for the development of new drugs by struggling pharmaceutical companies. This book describes the step-by-step use of proteomic methods such as two-dimensional gel electrophoresis, multiplex immunoassay, liquid chromatography mass spectrometry (LC-MS) and selective reaction monitoring MS, to increase our understanding of these diseases, with the ultimate aim of improving patient care.

The volume will be of high interest to clinical scientists, physicians and pharmaceutical company scientists as it gives insights into the latest technologies enabling the revolution of personalized medicine.  It is of direct interest to both technical and bench biomarker scientists as it gives step by step instructions on how to carry out each of the protocols. It is also  of interest to researchers as each technique will be presented in the context of a specific neurological disorder, including Alzheimer's disease, multiple sclerosis, autism spectrum disorders, schizophrenia, major depressive disorder and bipolar disorder. 

Finally, it will also highlight the future research efforts in this field, which are endeavoring to convert proteomic platforms to the form of hand held devices which can be used in a point of care setting and return diagnostic results within the timeframe of a visit to the general practitioner.


mass spectrometry translational medicine two-dimensional gel electrophoresis immunoassay liquid chromatography pharmacology

Editors and affiliations

  • Paul C. Guest
    • 1
  1. 1.Department of Biochemistry and Tissue BiologyUniversity of Campinas (UNICAMP)CampinasBrazil

Bibliographic information

  • Book Title Proteomic Methods in Neuropsychiatric Research
  • Editors Paul C. Guest
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-52478-8
  • Softcover ISBN 978-3-319-84911-9
  • eBook ISBN 978-3-319-52479-5
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XII, 370
  • Number of Illustrations 10 b/w illustrations, 45 illustrations in colour
  • Topics Proteomics
    Gene Expression
    Gene Therapy
  • Buy this book on publisher's site
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