MIF Family Cytokines in Innate Immunity and Homeostasis

  • Richard Bucala
  • Jürgen Bernhagen

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Shirly Becker-Herman, Naama Gil, Lihi Radomir, Idit Shachar
    Pages 1-20
  3. Ramona Schulz-Heddergott, Ute M. Moll
    Pages 21-42
  4. Kavitha Yaddanapudi, Robert A. Mitchell
    Pages 59-76
  5. Saisha A. Nalawade, Yousef Al-Abed, Thomas G. Forsthuber
    Pages 77-95
  6. Gil Benedek, Roberto Meza-Romero, Arthur A. Vandenbark
    Pages 97-107
  7. Veronica Marin, Gemma Odena, Kyle Poulsen, Claudio Tiribelli, Stefano Bellentani, Andrea Barchetti et al.
    Pages 109-134
  8. Timothy Baker, Patty J. Lee, Maor Sauler
    Pages 135-144
  9. Fei Ma, Katherine L. Meyer-Siegler, Karin N. Westlund, Pedro L. Vera
    Pages 145-155
  10. Christian Stoppe, Jürgen Bernhagen
    Pages 157-174
  11. Lara J. Herrero, Ali Zaid, Margit Mutso, Suresh Mahalingam
    Pages 175-187
  12. Marcelo T. Bozza, Claudia N. Paiva, Priscilla C. Olsen
    Pages 189-202
  13. Cesar Terrazas, James C. Stock, Jeniffer Kimble, Ellen Moretti, Sanjay Varikuti, Abhay R. Satoskar
    Pages 203-219
  14. Thomas Holowka, Richard Bucala
    Pages 221-239
  15. Back Matter
    Pages 241-246

About this book


The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses.  MIF’s molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized.  MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.


Infectious Diseases MIF Biology MIF-directed therapies MMIF Macrophage Migration Inhibitory Factor (MIF) Parasite MIF Orthologs

Editors and affiliations

  • Richard Bucala
    • 1
  • Jürgen Bernhagen
    • 2
  1. 1.The Anlyan Center, Yale School of MedicineYale UniversityNew HavenUSA
  2. 2.Department of Vascular Biology, Institute for Stroke and Dementia ResearchLudwig-Maximilians-University (LMU)MunichGermany

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-52352-1
  • Online ISBN 978-3-319-52354-5
  • Buy this book on publisher's site