© 2017

Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma

  • Juan Pedro Martinez-Barbera
  • Cynthia Lilian Andoniadou

Table of contents

  1. Front Matter
    Pages i-xii
  2. Annett Hölsken
    Pages 1-26
  3. Leslie Robinson, Sandro Santagata, Todd C. Hankinson
    Pages 27-39
  4. Cynthia Lilian Andoniadou, Juan Pedro Martinez-Barbera
    Pages 41-55
  5. Ashley J. Vardon, Niki Karavitaki
    Pages 57-66
  6. Hoong-Wei Gan, Helen A. Spoudeas, Mehul T. Dattani
    Pages 67-83
  7. Babita Jyoti, Daniel J. Indelicato, Julie A. Bradley, Ronny L. Rotondo
    Pages 101-135
  8. Kristian Aquilina, Michael Buchfelder
    Pages 137-158
  9. Back Matter
    Pages 215-220

About this book


This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches.

Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underlie the etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke’s pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.      


Stem cell adult pituitary stem cells pituitary development radiology tumor biology

Editors and affiliations

  • Juan Pedro Martinez-Barbera
    • 1
  • Cynthia Lilian Andoniadou
    • 2
  1. 1.Developmental Biology and Cancer Programme, Birth Defects Research Centre, Institute of Child HealthUniversity College LondonLondonUnited Kingdom
  2. 2.Craniofacial Development and Stem Cell BiologyKing’s College LondonLondonUnited Kingdom

About the editors

Professor Juan Pedro Martínez-Barberá is a leading expert in pituitary development and associated congenital disorders. He is a researcher at the Birth Defects Research Centre, Developmental Biology and Cancer Programme of the UCL Great Ormond Street Institute of Child Health.
Dr. Cynthia Lilian Andoniadou is a researcher at the Department of Craniofacial Development and Stem Cell Biology of King’s College London focusing on the biology of normal and pathogenic pituitary stem cells.

Bibliographic information

  • Book Title Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma
  • Editors Juan Pedro Martinez-Barbera
    Cynthia Lilian Andoniadou
  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-51888-6
  • Softcover ISBN 978-3-319-84770-2
  • eBook ISBN 978-3-319-51890-9
  • Edition Number 1
  • Number of Pages XII, 220
  • Number of Illustrations 15 b/w illustrations, 32 illustrations in colour
  • Topics Endocrinology
    Cancer Research
    Stem Cells
  • Buy this book on publisher's site
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Internal Medicine & Dermatology