Alternate Fractionation in Radiotherapy

Paradigm Change

  • Mark Trombetta
  • Jean-Philippe Pignol
  • Paolo Montemaggi
  • Luther W. Brady

Part of the Medical Radiology book series (MEDRAD)

Also part of the Radiation Oncology book sub series (Med Radiol Radiat Oncol)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Theodore E. Yaeger, Paolo Montemaggi, Mark Trombetta, Jean-Philippe Pignol, Luther Brady
    Pages 1-4
  3. Alan E. Nahum, Richard P. Hill
    Pages 5-19
  4. Brian J. Gebhardt, Zachary D. Horne, Sushil Beriwal
    Pages 41-63
  5. Mark Trombetta, Janusz Skowronek
    Pages 65-73
  6. Disease Site Specific Topics

    1. Front Matter
      Pages 75-75
    2. Olgun Elicin, E. Mahmut Ozsahin
      Pages 91-126
    3. Fernand Missohou, Mark Trombetta, Jean-Philippe Pignol
      Pages 127-139
    4. Jean-Philippe Pignol, Nienke Hoekstra, Fernand Missohou, Mark Trombetta
      Pages 141-155
    5. Mauro Loi, J.J. Nuyttens
      Pages 157-172
    6. Alejandra Méndez Romero, Thomas B. Brunner, Alexander V. Kirichenko, Wolfgang A. Tomé, Yun Liang, Nathan Ogden et al.
      Pages 173-201
    7. Alexander Kirichenko, Eugene J. Koay, Shaakir Hasan, Christopher Crane
      Pages 203-210
    8. Linda Chen, Lauren M. Rosati, Joseph M. Herman
      Pages 211-227
    9. Te Vuong, Slobodan Devic, Krzysztof Bujko
      Pages 229-239
    10. Joanne Jang, Patrizia Guerrieri, Akila N. Viswanathan
      Pages 257-272
    11. Gargi Kothari, Simon S. Lo, Matthew Foote, Arjun Sahgal, Irene Karam, Michael Lock et al.
      Pages 323-395
    12. Srinivas Raman, Natalie Logie, Joshua Jones, Eric Chang, Steven Lutz, Edward Chow
      Pages 397-418
  7. Alan E. Nahum, Richard P. Hill
    Pages 419-419
  8. Back Matter
    Pages 421-432

About this book


This book, written by leading international experts, describes alternate fractionation strategies in which technology-driven precise targeting and dosing allow for improved conformance and decreased volumes, with concordant lessening of toxicity, reduction in treatment time, and lower overall health care expense. The aim is to provide the advanced clinician with an up-to-date evidence-based reference that will assist in the delivery of enhanced patient care in daily practice.

Traditional multi-week fractionation schedules were established at a time when the inclusion of relatively large amounts of normal tissue was unavoidable owing to the lack of accurate target localization during treatment. Such schedules are time and resource consuming, difficult for patients, and expensive. Nevertheless, acceptance of alternate fractionation strategies has been slow in some countries. The paradigm is, however, changing as evidence accumulates to demonstrate improved local control, equivalence of tolerance, or both. In documenting these alternate strategies, this book will be of value for radiation oncologists, medical physicists, and oncologists worldwide.


Alternate Fractionation Brachytherapy Hypofractionation Technology-driven Precise Targeting Treatment Planning in Radiation Oncology Lessening of Toxicity Evidence-based Alternate Fractionation Rrecise Dosing and Targeting Beam delivery

Editors and affiliations

  • Mark Trombetta
    • 1
  • Jean-Philippe Pignol
    • 2
  • Paolo Montemaggi
    • 3
  • Luther W. Brady
    • 4
  1. 1.Allegheny General Hospital Allegheny Health Network Cancer InstituteDrexel University College of MedicinePittsburghUSA
  2. 2.Radiation Oncology DepartmentErasmus University Medical CenterRotterdamThe Netherlands
  3. 3.Allegheny Health NetworkTemple University School of MedicinePittsburghUSA
  4. 4.Hylda Cohn/American Cancer SocietyDrexel University College of MedicinePhiladelphiaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-51197-9
  • Online ISBN 978-3-319-51198-6
  • Series Print ISSN 0942-5373
  • Series Online ISSN 2197-4187
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Oncology & Hematology