© 2017

Inflammation-Associated Depression: Evidence, Mechanisms and Implications

  • Robert Dantzer
  • Lucile Capuron

Part of the Current Topics in Behavioral Neurosciences book series (CTBN, volume 31)

Table of contents

  1. Front Matter
    Pages i-x
  2. Celina S. Liu, Alexander Adibfar, Nathan Herrmann, Damien Gallagher, Krista L. Lanctôt
    Pages 3-30
  3. Barbara Strasser, Barbara Sperner-Unterweger, Dietmar Fuchs, Johanna M. Gostner
    Pages 95-115
  4. Christopher R. Pryce, Adriano Fontana
    Pages 139-154
  5. Caitlín N. M. Hastings, Hannah Sheridan, Carmine M. Pariante, Valeria Mondelli
    Pages 321-338

About this book


Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book “Inflammation-Associated Depression” is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level.


Biological Psychiatry Depression Inflammation Cytokine Indoleamine 2,3 dioxygenase Kynurenine Phenylalanine Tetrahydrobiopterin Obesity Cardiovascular disorders

Editors and affiliations

  • Robert Dantzer
    • 1
  • Lucile Capuron
    • 2
  1. 1.Department of Symptom ResearchThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Nutrition and Integrative NeurobiologyINRA, University of BordeauxBordeauxFrance

Bibliographic information

  • Book Title Inflammation-Associated Depression: Evidence, Mechanisms and Implications
  • Editors Robert Dantzer
    Lucile Capuron
  • Series Title Current Topics in Behavioral Neurosciences
  • Series Abbreviated Title Curr.Topics Behav.Neurosci.
  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-51151-1
  • Softcover ISBN 978-3-319-84581-4
  • eBook ISBN 978-3-319-51152-8
  • Series ISSN 1866-3370
  • Series E-ISSN 1866-3389
  • Edition Number 1
  • Number of Pages X, 356
  • Number of Illustrations 10 b/w illustrations, 20 illustrations in colour
  • Topics Neurosciences
    Health Psychology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals


“This book covers important and growing field of knowledge associated with the role of inflammation in depression. … The book is well written and presented with many diagrams and illustrations. It covers the gap in this area of psychiatry research and potential for clinical practice and will be of interest for clinicians and researchers worldwide.” (Branka Aukst Margetic, Alcoholism and Psychiatry Research, Vol. 54 (01), June, 2018)

“The authors describe the current research data surrounding the role of inflammation and its impact on depression. … Each chapter begins with an abstract, identified keywords, and an outline of the chapter. Most chapters contain helpful graphics and conclude with references. … To my knowledge, this is the first book focused solely on the role of inflammation in psychiatry, which was confirmed by a quick internet search.” (Aaron Plattner, Doody’s Book Reviews, April, 2017)