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© 2017

Liquid Biopsies in Solid Tumors

  • Massimo Cristofanilli

Benefits

  • Liquid biopsy is a new and exciting diagnostic field in breast cancer

  • Novel technologies allows for a real-time, minimally invasive, longitudinal assessment of molecular characteristics of the disease

  • Liquid biopsy can be used as tool to assess efficacy in advanced breast cancer and can be used for the molecular detection of minimally residual disease

  • Understanding the technical aspects, clinical and diagnostic applications for liquid biopsy is critical for medical oncologist that want to advance precision medicine

Book

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

About this book

Introduction

This volume, with chapters written by experts in the field of cancerous tumors, details the key factors associated with liquid biopsies in solid tumors: blood-based diagnostics; circulating tumor cells; enumeration and molecular analysis (association with breast cancer); epithelialmesenchymal transition; detection and monitoring; circulating-free tumor DNA; CTCs and ctDNA; and the exosome. The field of blood-based diagnostics is rapidly evolving demonstrating the possibility of real-time molecular analysis of cancer cells and their phenotype and genotype.

Circulating Tumor Cell (CTCs) have demonstrated prognostic and predictive value in advanced cancer and represents a source of tumor cells for transcriptome and genomic analysis. Most recently, the detection of genomic abnormalities in the peripheral blood by sensitive and selective PCR methods (liquid biopsy) opened to the option of a comprehensive blood-based tumor analysis. Similar information can be obtained by analysis of exosome, a natural packaging and messaging system being explored in advanced malignancies. The final frontier is the evaluation of immune cells determinant of innate and adaptive immunity.


Keywords

Liquid biopsies Tumors Blood-based diagnostics metastatic disease circulating immune cells

Editors and affiliations

  • Massimo Cristofanilli
    • 1
  1. 1.Department of Medicine-Hematology and OncologyRobert H. Lurie Comprehensive Cancer Center, Northwestern UniversityChicagoUSA

About the editors

Massimo Crisofanilli, MD, F.A.C.P, is Professor of Medical Oncology, Department of Medical Oncology, Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA.

Bibliographic information

  • Book Title Liquid Biopsies in Solid Tumors
  • Editors Massimo Cristofanilli
  • Series Title Cancer Drug Discovery and Development
  • Series Abbreviated Title Cancer Drug Discovery,Development
  • DOI https://doi.org/10.1007/978-3-319-50956-3
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Humana Press, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-50955-6
  • Softcover ISBN 978-3-319-84530-2
  • eBook ISBN 978-3-319-50956-3
  • Series ISSN 2196-9906
  • Series E-ISSN 2196-9914
  • Edition Number 1
  • Number of Pages X, 161
  • Number of Illustrations 2 b/w illustrations, 12 illustrations in colour
  • Topics Cancer Research
  • Buy this book on publisher's site
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Reviews

“The book 'Liquid biopsies in solid tumours' provides an overview of currently available technological approaches and clinical applications of liquid biopsies that offer an attractive alternative to invasive tumour biopsies. … This book collects contribution from experts in the field of blood-based diagnostics. They help us to understand the future of early cancer detection, characterization and monitoring via liquid biopsies strategies, providing clinicians with the advantage to understand, predict and intervene.” ( Bozena Smolkova, Neoplasma, Vol. 65 (1), January, 2018)