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Liquid Biopsies in Solid Tumors

  • Massimo Cristofanilli

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

About this book

Introduction

This volume, with chapters written by experts in the field of cancerous tumors, details the key factors associated with liquid biopsies in solid tumors: blood-based diagnostics; circulating tumor cells; enumeration and molecular analysis (association with breast cancer); epithelialmesenchymal transition; detection and monitoring; circulating-free tumor DNA; CTCs and ctDNA; and the exosome. The field of blood-based diagnostics is rapidly evolving demonstrating the possibility of real-time molecular analysis of cancer cells and their phenotype and genotype.

Circulating Tumor Cell (CTCs) have demonstrated prognostic and predictive value in advanced cancer and represents a source of tumor cells for transcriptome and genomic analysis. Most recently, the detection of genomic abnormalities in the peripheral blood by sensitive and selective PCR methods (liquid biopsy) opened to the option of a comprehensive blood-based tumor analysis. Similar information can be obtained by analysis of exosome, a natural packaging and messaging system being explored in advanced malignancies. The final frontier is the evaluation of immune cells determinant of innate and adaptive immunity.


Keywords

Liquid biopsies Tumors Blood-based diagnostics metastatic disease circulating immune cells

Editors and affiliations

  • Massimo Cristofanilli
    • 1
  1. 1.Department of Medicine-Hematology and OncologyRobert H. Lurie Comprehensive Cancer Center, Northwestern UniversityChicagoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-50956-3
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Humana Press, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-50955-6
  • Online ISBN 978-3-319-50956-3
  • Series Print ISSN 2196-9906
  • Series Online ISSN 2196-9914
  • Buy this book on publisher's site
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