© 2017

Sigma Receptors: Their Role in Disease and as Therapeutic Targets

  • Sylvia B. Smith
  • Tsung-Ping Su

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 964)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Assaf Alon, Hayden Schmidt, Sanduo Zheng, Andrew C. Kruse
    Pages 5-13
  3. Felipe Ossa, Jason R. Schnell, José Luis Ortega-Roldan
    Pages 15-29
  4. Frauke Weber, Peter Brust, Erik Laurini, Sabrina Pricl, Bernhard Wünsch
    Pages 31-48
  5. Olivier Soriani, Raphaël Rapetti-Mauss
    Pages 63-77
  6. Shang-Yi Anne Tsai, Tsung-Ping Su
    Pages 79-83
  7. Manuel Merlos, Javier Burgueño, Enrique Portillo-Salido, Carlos Ramón Plata-Salamán, José Miguel Vela
    Pages 85-107
  8. Cristina Sánchez-Fernández, José Manuel Entrena, José Manuel Baeyens, Enrique José Cobos
    Pages 109-132
  9. Linda Nguyen, Brandon P. Lucke-Wold, Shona Mookerjee, Nidhi Kaushal, Rae R. Matsumoto
    Pages 133-152
  10. Yu Cai, Lu Yang, Fang Niu, Ke Liao, Shilpa Buch
    Pages 163-175
  11. Valentina Sabino, Callum Hicks, Pietro Cottone
    Pages 177-199
  12. Renzo Mancuso, Xavier Navarro
    Pages 235-254
  13. Timur A. Mavlyutov, Erin M. Baker, Tasher M. Losenegger, Jaimie R. Kim, Brian Torres, Miles L. Epstein et al.
    Pages 255-265
  14. Jing Wang, Xuezhi Cui, Penny Roon, Alan Saul, Sylvia B. Smith
    Pages 267-284
  15. Timur A. Mavlyutov, Lian-Wang Guo
    Pages 285-297

About this book


Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types.  It’s putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors.  Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.


Drug Target Molecular Chaperone Neurodegeneration Neuroprotection Sigma 1 Receptor

Editors and affiliations

  • Sylvia B. Smith
    • 1
  • Tsung-Ping Su
    • 2
  1. 1.Departments of Cellular Biology and Anatomy and Ophthalmology and the James and Jean Culver Vision Discovery InstituteMedical College of Georgia at Augusta UniversityAugustaUSA
  2. 2.Cellular Pathobiology Section, Integrative Neuroscience Research Branch, Intramural Research ProgramNational Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human ServicesBaltimoreUSA

Bibliographic information

  • Book Title Sigma Receptors: Their Role in Disease and as Therapeutic Targets
  • Editors Sylvia B. Smith
    Tsung-Ping Su
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer International Publishing AG (outside the USA) 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-50172-7
  • Softcover ISBN 978-3-319-84335-3
  • eBook ISBN 978-3-319-50174-1
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XIII, 312
  • Number of Illustrations 14 b/w illustrations, 45 illustrations in colour
  • Topics Biomedicine, general
    Protein Science
  • Buy this book on publisher's site
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