SUMO Regulation of Cellular Processes

  • Van G. Wilson

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 963)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Van G. Wilson
    Pages 1-12
  3. Molecular Functions

    1. Front Matter
      Pages 13-13
    2. Patricia Richard, Vasupradha Vethantham, James L. Manley
      Pages 15-33
    3. David Wotton, Lucy F. Pemberton, Jacqueline Merrill-Schools
      Pages 35-50
    4. Nicola Zilio, Karolin Eifler-Olivi, Helle D. Ulrich
      Pages 51-87
    5. Christopher Ptak, Richard W. Wozniak
      Pages 111-126
    6. Mark Benson, Jorge A. Iñiguez-lluhí, Jeffrey Martens
      Pages 127-141
    7. Elena Kamynina, Patrick J. Stover
      Pages 143-168
  4. Cell Growth Regulation

    1. Front Matter
      Pages 169-169
    2. Debaditya Mukhopadhyay, Mary Dasso
      Pages 171-184
    3. Amanda C. Nottke, Hyun-Min Kim, Monica P. Colaiácovo
      Pages 185-196
    4. Adeline F. Deyrieux, Van G. Wilson
      Pages 197-214
    5. Lyndee L. Scurr, Sebastian Haferkamp, Helen Rizos
      Pages 215-226
    6. Joseph Cao, Albert J. Courey
      Pages 249-257
  5. Diseases

    1. Front Matter
      Pages 259-259
    2. Dina B. Anderson, Camila A. Zanella, Jeremy M. Henley, Helena Cimarosti
      Pages 261-281
    3. Jason S. Lee, Hee June Choi, Sung Hee Baek
      Pages 283-298
    4. Jing Zhang, Zhishui Chen, Zhiguang Zhou, Ping Yang, Cong-Yi Wang
      Pages 299-322
    5. Erwin Pauws, Philip Stanier
      Pages 323-335
    6. Jun-ichi Abe, Uday G. Sandhu, Nguyet Minh Hoang, Manoj Thangam, Raymundo A. Quintana-Quezada, Keigi Fujiwara et al.
      Pages 337-358
  6. Back Matter
    Pages 409-415

About this book


This is the second edition of a very well received book that details how the sumoylation system functions and how it modulates numerous cellular activities. SUMO is a post-translational modifier in the ubiquitin super-family that has gained recognition over the last twenty years as an essential and prevalent regulatory molecule.

Individual chapters explore the biochemistry, molecular biology, and cell biology of the sumoylation system and its substrate proteins.

The book is divided into three themed parts: Molecular Functions (I), Cell Growth Regulation (II), and Diseases (III). Parts I and II focus on the contribution of sumoylation to cellular activities in both the nuclear and cytoplasmic compartments. The nuclear activities covered include nucleic acid metabolism (both RNA and DNA), chromosome structure and replication, and nucleocytoplasmic transport. Cytoplasmic processes presented include regulation of membrane ion channels, general metabolism, and apoptotic signalling. Topics in Part III include the role of sumoylation in developmental abnormalities (craniofacial and cardiovascular), diabetes, neurodegenerative diseases, cancer, and infections with viruses and bacteria.

Each of the corresponding chapter authors is an active researcher who has made significant contributions to understanding sumoylation. This second edition provides updates and revisions to most of the original chapters plus adds six new chapters to address important developing areas of sumoylation research.

This volume is intended for a scientific audience from undergraduates to independent researchers. The content will serve as both a solid introduction for the novice reader and an in depth treatment for the advanced scholar.


DNA Translation cellular processes molecular mechanisms post-translational modification regulation Sumoylation Ubc9 Protein biochemistry

Editors and affiliations

  • Van G. Wilson
    • 1
  1. 1.Department of Microbial Pathogenesis and Immunology, College of MedicineTexas A&M Health Science CenterBryanUSA

Bibliographic information

Industry Sectors
Health & Hospitals
Consumer Packaged Goods