Progress in the Chemistry of Organic Natural Products 105

  • A. Douglas Kinghorn
  • Heinz Falk
  • Simon Gibbons
  • Jun'ichi Kobayashi

Part of the Progress in the Chemistry of Organic Natural Products book series (POGRCHEM, volume 105)

Table of contents

  1. Front Matter
    Pages i-v
  2. Hiroshi Ashihara, Kouichi Mizuno, Takao Yokota, Alan Crozier
    Pages 1-88
  3. Catherine Lavaud, Georges Massiot
    Pages 89-136

About this book


The first contribution reviews the occurrence of xanthine alkaloids in the plant kingdom and the elucidation of the caffeine biosynthesis pathway, providing details of the N-methyltransferases, belonging to the motif B' methyltransferase family which catalyze three steps in the four step pathway leading from xanthosine to caffeine. The second contribution in this book provides a background on the molecule and related compounds and update knowledge on the most recent advances in Iboga alkaloids.  The third contribution presents a comprehensive analysis of frequently occurring errors with respect to 13C NMR spectroscopic data and proposes a straightforward protocol to eliminate a high percentage of the most obvious errors.


computer-assisted structure elucidation spectrum perdiction isomer generation methylxanthines caffeine Camellia sinensis structural elucidation drug cessation treatment

Editors and affiliations

  • A. Douglas Kinghorn
    • 1
  • Heinz Falk
    • 2
  • Simon Gibbons
    • 3
  • Jun'ichi Kobayashi
    • 4
  1. 1.Division of Medicinal Chemistry & Pharmacognosy, College of PharmacyThe Ohio State UniversityColumbusUSA
  2. 2.Institute of Organic ChemistryJohannes Kepler University LinzLinzAustria
  3. 3.Research Department of Pharmaceutical and Biological ChemistryUCL School of PharmacyLondonUnited Kingdom
  4. 4.Graduate School of Pharmaceutical ScienceHokkaido UniversitySapporoJapan

Bibliographic information

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