The Neuropilins: Role and Function in Health and Disease

  • Gera Neufeld
  • Ofra Kessler

Table of contents

  1. Front Matter
    Pages i-vi
  2. Gera Neufeld, Ofra Kessler
    Pages 1-6
  3. Molecular Mechanisms of Neuropilin Mediated Signal Transduction

  4. Neuropilins as Regulators of Developmental and Immune Processes

    1. Front Matter
      Pages 91-91
    2. James T. Brash, Anastasia Lampropoulou, Christiana Ruhrberg
      Pages 93-107
    3. Jinah Han, Georgia Zarkada, Anne Eichmann
      Pages 109-124
    4. Michael W. Shiflett, Edward Martinez, Hussein Khdour, Tracy S. Tran
      Pages 125-149
    5. Satoshi Nojima, Atsushi Kumanogoh
      Pages 151-160
  5. The Role of the Neuropilins in Cancer and in Immune Disorders

    1. Front Matter
      Pages 161-161
    2. Dan Liu, Marwa Mahmoud, Carla Milagre, Ian Zachary, Paul Frankel
      Pages 163-186
    3. Gérald J. Prud’homme, Yelena Glinka, Pratiek N. Matkar, Howard Leong-Poi
      Pages 187-212
    4. Zahava Vadasz
      Pages 225-232
  6. Back Matter
    Pages 233-239

About this book


This book covers basic research topics such as the structure-function relationships of neuropilins and mechanisms of neuropilin-mediated signal transduction, details the most important roles of the neuropilins in developmental biology, and addresses their roles in various conditions such as cancer and various eye diseases.

The two neuropilin genes encode scaffold receptors that can bind several different ligands, and also associate with many other receptors and modify their activity. Further, it has been confirmed that they play important roles in the shaping of major organs and tissues such as the nervous system and the vascular system, and that they can modulate immune responses.

The book offers a helpful guide for biomedical researchers and all scientists active in the neurosciences, vascular and molecular biology, as well as developmental biology and immunology.


angiogenesis antigen recognition axon guidance neuropilin tumor progression vascular biology

Editors and affiliations

  • Gera Neufeld
    • 1
  • Ofra Kessler
    • 2
  1. 1.Department Anatomy and Cell BiologyIsrael Institute of Technology TechnionHaifaIsrael
  2. 2.Department Anatomy and Cell BiologyIsrael Institute of Technology TechnionHaifaIsrael

Bibliographic information

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