© 2017


Definitions, Pathophysiology and the Challenge of Bedside Management

  • Nicholas S. Ward
  • Mitchell M. Levy
  • Provides a comprehensive and state-of-the-art resource

  • Reviews emerging concepts and approaches

  • Contains the latest scientific and clinical developments


Part of the Respiratory Medicine book series (RM)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Part I

    1. Front Matter
      Pages 1-1
    2. Mitchell M. Levy, Nicholas S. Ward
      Pages 3-5
    3. Debasree Banerjee, Mitchell M. Levy
      Pages 7-24
    4. Bashar Staitieh, Greg S. Martin
      Pages 25-43
  3. Part II

    1. Front Matter
      Pages 45-45
    2. Tristen T. Chun, Brittany A. Potz, Whitney A. Young, Alfred Ayala
      Pages 47-69
    3. Nicholas Csikesz, Nicholas S. Ward
      Pages 71-87
    4. Andre C. Kalil, Steven M. Opal
      Pages 89-104
  4. Part III

    1. Front Matter
      Pages 105-105
    2. Douglas R. Closser, Mathew C. Exline, Elliott D. Crouser
      Pages 107-126
    3. Hernando Gomez, Alex Zarbock, Raghavan Murugan, John A. Kellum
      Pages 127-142
    4. MaryEllen Antkowiak, Lucas Mikulic, Benjamin T. Suratt
      Pages 143-157
  5. Part IV

    1. Front Matter
      Pages 185-185
    2. Michael Connolly, Charles Adams
      Pages 207-218
    3. Jean-Louis Vincent
      Pages 219-224
    4. Laura Evans, William Bender
      Pages 225-236
    5. John P. Reilly, Nuala J. Meyer, Jason D. Christie
      Pages 237-264

About this book


This book is designed to provide a comprehensive and state-of-the-art resource for clinicians who care for patients with sepsis and research scientist alike, . Patients with severe sepsis requiring ICU admission have very high rates of ICU and overall hospital mortality, with estimates ranging from 18 to 50%. Risk factors for death from sepsis include underlying illness, increased age, and multi-system organ failure. This is compounded by the significant variation in the management of early severe sepsis. Care of these patients and clinical conditions can be quite complex, and materials are collected from the most current, evidence-based resources. Book sections have been structured to review the overall definitions and epidemiology of sepsis as well as current insights into the pathophysiology of sepsis. This review summarizes the evidence for the international consensus guidelines for the identification and management of sepsis. The latter part of this book reviews emerging concepts and approaches in the diagnosis and management of sepsis that may significantly reduce mortality in the future. Sepsis: Pathophysiology, Definitions and the Challenge of Bedside Management represents a collaboration between authors drawn from a variety of disciplines and contributions from basic scientists and highly recognized clinical opinion leaders with expertise in clinical trials.​


Acute renal failure Bundled therapy Coagulation system Hemodynamic support Hyper inflammation Organ failure

Editors and affiliations

  • Nicholas S. Ward
    • 1
  • Mitchell M. Levy
    • 2
  1. 1.Division of Pulmonary Critical Care, and Sleep MedicineAlpert/Brown Medical SchoolProvidenceUSA
  2. 2.Division of Pulmonary Critical Care, and Sleep MedicineAlpert/Brown Medical SchoolProvidenceUSA

About the editors

Dr. Ward joined the Brown faculty in 1999 after completing his pulmonary/critical care training at Yale- New Haven Hospital. His past research interests have included mechanisms of acute lung injury, mechanical ventilation of acute lung injury, and sepsis. His current research focuses on rationing, ethics and ICU resource utilization. In addition to research, Dr. Ward attends in the Medical Intensive Care Unit, the Neuro ICU, and the pulmonary consultation service. He also lectures in the Pulmonary Pathophysiology course and is the co- course director. Dr. Ward is a member of the Medical School curriculum committee, the Rhode Island hospital ethics committee, and is the pulmonary/critical care fellowship director. Dr. Levy is medical director of the Medical Intensive Care Unit at Rhode Island Hospital and professor of medicine and division chief of pulmonary and critical care medicine at The Warren Alpert Medical School of Brown University in Providence, RI. Dr. Levy is a council member of the Society of Critical Care Medicine and is co-chair of the Surviving Sepsis Campaign Management Guidelines Committee. He also serves as a senior editor for the Journal of Critical Care as well as chair of the Robert Wood Johnson Critical Care End-of-Life Work Group, a group he has led since its inception in 1998. Dr. Levy has held leadership positions in the American College of Chest Physicians and the American Thoracic Society. In 2001, Levy chaired the International Educational and Scientific Symposium of the Society of Critical Care Medicine, an organization that also awarded Levy its Award of Ethics and Distinguished Service Award. Upon receiving his medical degree from the University of Buffalo, Levy completed his residency training at the University of Colorado Health System. He is a fellow of the American College of Critical Care Medicine and the American College of Chest Physicians.

Bibliographic information

  • Book Title Sepsis
  • Book Subtitle Definitions, Pathophysiology and the Challenge of Bedside Management
  • Editors Nicholas S. Ward
    Mitchell M. Levy
  • Series Title Respiratory Medicine
  • Series Abbreviated Title Respiratory Medicine
  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Humana Press, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-48468-6
  • Softcover ISBN 978-3-319-83950-9
  • eBook ISBN 978-3-319-48470-9
  • Series ISSN 2197-7372
  • Series E-ISSN 2197-7380
  • Edition Number 1
  • Number of Pages XI, 271
  • Number of Illustrations 8 b/w illustrations, 8 illustrations in colour
  • Topics Pneumology/Respiratory System
    Intensive / Critical Care Medicine
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology