Definitions, Pathophysiology and the Challenge of Bedside Management

  • Nicholas S. Ward
  • Mitchell M. Levy

Part of the Respiratory Medicine book series (RM)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Part I

    1. Front Matter
      Pages 1-1
    2. Mitchell M. Levy, Nicholas S. Ward
      Pages 3-5
    3. Debasree Banerjee, Mitchell M. Levy
      Pages 7-24
    4. Bashar Staitieh, Greg S. Martin
      Pages 25-43
  3. Part II

    1. Front Matter
      Pages 45-45
    2. Tristen T. Chun, Brittany A. Potz, Whitney A. Young, Alfred Ayala
      Pages 47-69
    3. Nicholas Csikesz, Nicholas S. Ward
      Pages 71-87
    4. Andre C. Kalil, Steven M. Opal
      Pages 89-104
  4. Part III

    1. Front Matter
      Pages 105-105
    2. Douglas R. Closser, Mathew C. Exline, Elliott D. Crouser
      Pages 107-126
    3. Hernando Gomez, Alex Zarbock, Raghavan Murugan, John A. Kellum
      Pages 127-142
    4. MaryEllen Antkowiak, Lucas Mikulic, Benjamin T. Suratt
      Pages 143-157
  5. Part IV

    1. Front Matter
      Pages 185-185
    2. Michael Connolly, Charles Adams
      Pages 207-218
    3. Jean-Louis Vincent
      Pages 219-224
    4. Laura Evans, William Bender
      Pages 225-236
    5. John P. Reilly, Nuala J. Meyer, Jason D. Christie
      Pages 237-264
  6. Back Matter
    Pages 265-271

About this book


This book is designed to provide a comprehensive and state-of-the-art resource for clinicians who care for patients with sepsis and research scientist alike, . Patients with severe sepsis requiring ICU admission have very high rates of ICU and overall hospital mortality, with estimates ranging from 18 to 50%. Risk factors for death from sepsis include underlying illness, increased age, and multi-system organ failure. This is compounded by the significant variation in the management of early severe sepsis. Care of these patients and clinical conditions can be quite complex, and materials are collected from the most current, evidence-based resources. Book sections have been structured to review the overall definitions and epidemiology of sepsis as well as current insights into the pathophysiology of sepsis. This review summarizes the evidence for the international consensus guidelines for the identification and management of sepsis. The latter part of this book reviews emerging concepts and approaches in the diagnosis and management of sepsis that may significantly reduce mortality in the future. Sepsis: Pathophysiology, Definitions and the Challenge of Bedside Management represents a collaboration between authors drawn from a variety of disciplines and contributions from basic scientists and highly recognized clinical opinion leaders with expertise in clinical trials.​


Acute renal failure Bundled therapy Coagulation system Hemodynamic support Hyper inflammation Organ failure

Editors and affiliations

  • Nicholas S. Ward
    • 1
  • Mitchell M. Levy
    • 2
  1. 1.Division of Pulmonary Critical Care, and Sleep MedicineAlpert/Brown Medical SchoolProvidenceUSA
  2. 2.Division of Pulmonary Critical Care, and Sleep MedicineAlpert/Brown Medical SchoolProvidenceUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Humana Press, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-48468-6
  • Online ISBN 978-3-319-48470-9
  • Series Print ISSN 2197-7372
  • Series Online ISSN 2197-7380
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology