Proteomics in Human Reproduction

Biomarkers for Millennials

  • Ashok Agarwal
  • Luna Samanta
  • Ricardo P. Bertolla
  • Damayanthi Durairajanayagam
  • Paula Intasqui

Part of the SpringerBriefs in Reproductive Biology book series (BRIEFSREPROBIO)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Luna Samanta, Damayanthi Durairajanayagam
    Pages 1-8
  3. Ricardo P. Bertolla
    Pages 9-20
  4. Nirlipta Swain, Gayatri Mohanty, Luna Samanta, Paula Intasqui
    Pages 21-43
  5. Nirlipta Swain, Caroline Cirenza, Luna Samanta
    Pages 45-63
  6. Luna Samanta
    Pages 65-69
  7. Gayatri Mohanty, Luna Samanta
    Pages 71-82
  8. Ricardo P. Bertolla
    Pages 83-92
  9. Luna Samanta, Damayanthi Durairajanayagam
    Pages 93-95
  10. Back Matter
    Pages 97-124

About this book


This Brief explores the use of proteomics as a tool for biomarker discovery in human reproduction and summarizes current findings and trends of proteomic studies in both male and female infertility. This simplifies this important but complex topic and equips the novice reader with sufficient background information on the use of proteomics in human reproduction. The up-to-date scenario on proteomic investigations will also appeal to researchers and post graduate students looking to keep abreast with the latest developments in reproductive research. This review summarizes current findings of contemporary proteomic studies on infertility in both males and females with various reproductive pathologies, and its use in predicting the outcome of assisted reproduction. In human reproduction, the search for biomarkers via proteomics is a fast-evolving approach that involves the analysis of proteins in the reproductive tissues and fluids, such as the male gametes, seminal plasma, ovarian and endometrial tissue, and follicular and uterine fluid. By comparing the protein profile of a healthy, fertile individual against that of an infertile individual, the differentially expressed proteins may give an indication to certain proteins that could serve as useful biomarkers that are related to infertility. As proteomic studies continue to unravel the dynamic proteome behind various infertility conditions, there is potential for the discovery of prognostic markers that could ultimately help in both natural and assisted human reproduction.


Assisted reproduction Biomarkers Human gamete proteome Infertility Protein expression

Authors and affiliations

  • Ashok Agarwal
    • 1
  • Luna Samanta
    • 2
  • Ricardo P. Bertolla
    • 3
  • Damayanthi Durairajanayagam
    • 4
  • Paula Intasqui
    • 5
  1. 1.Cleveland ClinicClevelandUSA
  2. 2.Department of ZoologyRavenshaw University Department of ZoologyCuttackIndia
  3. 3.Sao Paulo Federal University Sao PauloBrazil
  4. 4.Faculty of MedicineMARA University of TechnologyKuala LumpurMalaysia
  5. 5.Sao Paulo Federal University Sao PauloBrazil

Bibliographic information

Industry Sectors
Health & Hospitals