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© 2017

Human Retrotransposons in Health and Disease

  • Gael Cristofari
Book

Table of contents

  1. Front Matter
    Pages i-x
  2. Simon J. Newkirk, Wenfeng An
    Pages 29-61
  3. Tara T. Doucet-O’Hare, Haig H. Kazazian Jr.
    Pages 63-93
  4. Marie-Jeanne H. C. Kempen, Gabriela O. Bodea, Geoffrey J. Faulkner
    Pages 107-125
  5. Angela Macia, Leon Tejwani, Pinar Mesci, Alysson Muotri, Jose L. Garcia-Perez
    Pages 127-156
  6. Catherine M. Ade, Geraldine Servant, Maria E. Morales, Astrid M. Roy-Engel
    Pages 157-194
  7. Caroline Toudic, Xavier Elisseeff, Adjimon Gatien Lokossou, Benoit Barbeau
    Pages 215-238
  8. Maria E. Morales, Geraldine Servant, Catherine M. Ade, Prescott Deininger
    Pages 239-257
  9. Cristina Tufarelli, Richard M. Badge
    Pages 259-273
  10. Jill A. Kreiling, Brian C. Jones, Jason G. Wood, Marco De Cecco, Steven W. Criscione, Nicola Neretti et al.
    Pages 297-321
  11. Back Matter
    Pages 323-330

About this book

Introduction

This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80’s. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-mediated genome variations. These progresses have also led to the discovery that retrotransposon activity is not restricted to the germline - resulting in inheritable genetic variations - but can also mobilize in somatic tissues, such as embryonic stem cells, neuronal progenitor cells, or in many cancers. This book covers topics related to the effects of retrotransposon insertions, and their consequences on germline and somatic genome dynamics, but also discuss the role and impact of retrotransposons sequences in a broader context, including a number of novel topics that emerged recently (long non-coding RNA, neuronal disorders, exaptation) with unexpected connections between retrotransposons, stem cell maintenance, placentation, circadian cycles or aging.


Keywords

Epigenetics Genome Germline L1 lncRNA Mutagenesis

Editors and affiliations

  • Gael Cristofari
    • 1
  1. 1.Institute for Research on Cancer and Aging of Nice (IRCAN), French National Institute of Health and Medical Research (INSERM), Centre National de la Recherche Scientifique (CNRS), Faculty of MedicineUniversity of Nice-Sophia Antipolis (UNS), Université Côte d’Azur (UCA)NiceFrance

About the editors

Gael Cristofari is a biomedical expert in Molecular Biology & Genetics and Biology & Biochemistry at IRCAN, in Nice, France.

Bibliographic information

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