Bone Morphogenetic Proteins: Systems Biology Regulators

  • Slobodan Vukicevic
  • Kuber T. Sampath

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Kuber T. Sampath, A. Hari Reddi
    Pages 1-13
  3. Yuji Mishina, Nobuhiro Kamiya
    Pages 39-72
  4. Kristof Nolan, Thomas B. Thompson
    Pages 73-111
  5. Wei Ji, Johanna Bolander, Yoke Chin Chai, Hiroki Katagiri, Marina Marechal, Frank P. Luyten
    Pages 127-169
  6. Peter V. Giannoudis, Nikolaos K. Kanakaris
    Pages 187-214
  7. Lovorka Grgurevic, Igor Erjavec, Ivo Dumic-Cule, Tatjana Bordukalo-Niksic, Martina Pauk, Vladimir Trkulja et al.
    Pages 215-228
  8. Sachin Gupta, Vivek Mohan, Munish C. Gupta
    Pages 229-247
  9. Ulf M. E. Wikesjö, Cristiano Susin
    Pages 249-269
  10. Kuber T. Sampath, Lovorka Grgurevic, Slobodan Vukicevic
    Pages 271-291
  11. Lovorka Grgurevic, Ivo Dumic-Cule, Slobodan Vukicevic
    Pages 357-366
  12. Andreas Benn, Julia Haupt, Susanne Hildebrandt, Christian Kaehler, Petra Knaus
    Pages 367-407
  13. Back Matter
    Pages 435-445

About this book


This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit flies to mammals and are responsible for the formation of practically every organ during embryo development and involved in adult tissue injury and repair. BMPs establish their extracellular gradient by interacting with their respective antagonists and regulate their function through SMAD-dependent down-stream signaling effector genes.

This volume is aimed at scientists and professionals dealing with metabolic disorders, nutrition, systems biology diseases, rare musculoskeletal conditions, and disorders related to iron metabolism, including anemia of chronic disease, hereditary hemochromatosis and beta thalassemia.


BMPs biology BMPs in dental medicine BMPs in orthopedic medicine BMPs signaling in diseases BMP Antagonists

Editors and affiliations

  • Slobodan Vukicevic
    • 1
  • Kuber T. Sampath
    • 2
  1. 1.School of MedicineUniversity of ZagrebZagrebCroatia
  2. 2.perForm Biologics IncHollistonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-47505-9
  • Online ISBN 978-3-319-47507-3
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals