© 2017

The Actin Cytoskeleton

  • Brigitte M. Jockusch


  • Provides an up-to-date handbook on the organisation and dynamics of actin and the interaction with its companions

  • Presents the cutting-edge view on the role of the actin cytoskeleton in signalling pathways

  • Features the hot-topic research on the activity of toxins, viral and bacterial pathogens on the actin cytoskeleton

  • Introduces the present knowledge on the activity of actin on chromatin organisation, transcription and RNA transport


Part of the Handbook of Experimental Pharmacology book series (HEP, volume 235)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Christophe Ampe, Marleen Van Troys
    Pages 1-37
  3. Joseph W. Sanger, Jushuo Wang, Yingli Fan, Jennifer White, Lei Mi-Mi, Dipak K. Dube et al.
    Pages 39-75
  4. Thomas A. Masters, John Kendrick-Jones, Folma Buss
    Pages 77-122
  5. Jaakko Lehtimäki, Markku Hakala, Pekka Lappalainen
    Pages 123-152
  6. Anika Steffen, Theresia E. B. Stradal, Klemens Rottner
    Pages 153-178
  7. Klaus Aktories, Carsten Schwan, Alexander E. Lang
    Pages 179-206
  8. Guy Tran Van Nhieu, Stéphane Romero
    Pages 207-235
  9. N. Bishara Marzook, Timothy P. Newsome
    Pages 237-261
  10. Tiina Viita, Maria K. Vartiainen
    Pages 311-329
  11. Thomas D. Pollard
    Pages 331-347
  12. Back Matter
    Pages 349-351

About this book


Actin is one of the most abundant proteins and ubiquitously expressed in all eukaryotes. In recent years, the analysis of structure and function of such complexes has shed new light on actin's role in cellular and tissue morphogenesis, locomotion and various forms of intracellular motility, but also on its role in nuclear processes like chromatin architecture and transcription. Progress in understanding these different physiological phenomena, but also in unravelling the basis of actin-based pathophysiological processes has been made by combining video microscopy, molecular biology, genetics  and biochemistry. Thus, the current research on actin, as ongoing in many international laboratories, is a "hot spot" in basic and translational research in life sciences. In this book on  "The Actin Cytoskeleton", twelve internationally renowned authors present specific chapters that cover their recent work concerned with the various roles of actin mentioned above. This comprehensive volume is therefore an attractive handbook for teachers and students in many fields of medicine and pharmacology.


actin dynamics actin-based pathogens cell differentiation nuclear functions signalling pathways toxin targets

Editors and affiliations

  • Brigitte M. Jockusch
    • 1
  1. 1.Cell Biology, Life SciencesBRICS, TU BraunschweigBraunschweigGermany

Bibliographic information

  • Book Title The Actin Cytoskeleton
  • Editors Brigitte M. Jockusch
  • Series Title Handbook of Experimental Pharmacology
  • Series Abbreviated Title Hdb Exp.Pharmacology(formerly:Starke,K.:Eds)
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-46369-8
  • Softcover ISBN 978-3-319-83503-7
  • eBook ISBN 978-3-319-46371-1
  • Series ISSN 0171-2004
  • Series E-ISSN 1865-0325
  • Edition Number 1
  • Number of Pages XII, 352
  • Number of Illustrations 30 b/w illustrations, 30 illustrations in colour
  • Topics Pharmacology/Toxicology
    Cell Physiology
  • Buy this book on publisher's site
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