Nitrite and Nitrate in Human Health and Disease

  • Nathan S. Bryan
  • Joseph Loscalzo

Part of the Nutrition and Health book series (NH)

Table of contents

  1. Front Matter
    Pages i-xxxi
  2. Biochemistry, Molecular Biology, Metabolism and Physiology

    1. Front Matter
      Pages 1-1
    2. Nathan S. Bryan, Joseph Loscalzo
      Pages 3-10
    3. Mark Gilchrist, Nigel Benjamin
      Pages 11-19
    4. Nathan S. Bryan, Joseph F. Petrosino
      Pages 21-31
    5. Diane E. Handy, Joseph Loscalzo
      Pages 33-52
    6. Danielle A. Guimaraes, Chris Reyes, Sruti Shiva
      Pages 53-68
    7. Andrew L. Milkowski
      Pages 69-82
  3. Food and Environmental Exposures to Nitrite and Nitrate

  4. Nitrite and Nitrate in Therapeutics and Disease

    1. Front Matter
      Pages 163-163
    2. Nathan S. Bryan, Jack R. Lancaster Jr.
      Pages 165-178
    3. Kenneth D. Bloch, Andrea U. Steinbicker, Lisa Lohmeyer, Rajeev Malhotra
      Pages 179-193
    4. Thomas Münzel, Andreas Daiber
      Pages 195-216
    5. David J. Lefer, Nathan S. Bryan, Chelsea L. Organ
      Pages 217-234
    6. Lawrence C. Johnson, Allison E. DeVan, Jamie N. Justice, Douglas R. Seals
      Pages 259-277
    7. Stephen J. Bailey, Anni Vanhatalo, Andrew M. Jones
      Pages 293-310
    8. David M. Klurfield
      Pages 311-323
    9. Nathan S. Bryan, Joseph Loscalzo
      Pages 325-336
  5. Nathan S. Bryan, Jack R. Lancaster Jr.
    Pages E1-E1
  6. Back Matter
    Pages 337-349

About this book


This fully revised and updated new edition provides a comprehensive look at nitrite and nitrate and their effect on human health and disease. The first section describes the biochemical analysis of nitrite and nitrate and its role in human physiology. The book then shifts to sources of human exposure of nitrite and nitrate, including environmental and dietary. Finally, the last section discusses nitric oxide-based therapeutics and how nitrite and nitrate biochemistry can be safely harnessed to improve human health. Each chapter provides a balanced, evidence-based view and heavily cites the most recent published literature. They follow a strict chapter format which includes keywords, key points, a conclusion highlighting major findings, and extensive references.

The second edition contains new chapters on nitrite and nitrate in age medicine, nitrite and nitrate as a treatment for hypertension, and nitrite and nitrate in exercise performance. Additionally, the editors have expanded the biochemistry section to include chapters on nitrate reducing oral bacteria, nitrite mediated S-Nitrosation, epigenetics and the regulation of nitric oxide, and nitrite control of mitochondrial function.

Nitrate and Nitrite in Human Health and Disease, 2e, will be of interest to health professionals, nutritionists, dieticians, biomedical scientists, and food scientists.


Nitrate Nitric oxide (NO) Nitrite Nitrogen Oxide Nitrite and Nitrate in Cancer The Mitochondrion Atmospheric Nitroge Atmospheric Nitroge Nitric Oxide Pathway

Editors and affiliations

  • Nathan S. Bryan
    • 1
  • Joseph Loscalzo
    • 2
  1. 1.Department of Molecular and Human GeneticsBaylor College of MedicineHoustonUSA
  2. 2.Department of MedicineHarvard Medical SchoolBostonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Humana Press, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-46187-8
  • Online ISBN 978-3-319-46189-2
  • Buy this book on publisher's site
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