© 2017

Vertebrate Development

Maternal to Zygotic Control

  • Francisco Pelegri
  • Michael Danilchik
  • Ann Sutherland
  • Emphasizes underlying common molecular, cellular and developmental themes between vertebrates and pro-vertebrates

  • Uniquely focuses on the very earliest stages of development, at the transition between information provided by the mother in the egg and the regulation by genetic material of the embryo

  • Discusses nuclear transfer, a promising new tool with applications to regenerative medicine and conservation biology?


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 953)

Table of contents

  1. Front Matter
    Pages i-x
  2. Zoltan Machaty, Andrew R. Miller, Lu Zhang
    Pages 1-47
  3. Michael D. Sheets, Catherine A. Fox, Megan E. Dowdle, Susanne Imboden Blaser, Andy Chung, Sookhee Park
    Pages 49-82
  4. Andreas Heim, Beata Rymarczyk, Thomas U. Mayer
    Pages 83-116
  5. Andrew Hasley, Shawn Chavez, Michael Danilchik, Martin Wühr, Francisco Pelegri
    Pages 117-171
  6. Matias Escobar-Aguirre, Yaniv M. Elkouby, Mary C. Mullins
    Pages 173-207
  7. Douglas W. Houston
    Pages 209-306
  8. Wei-Chia Tseng, Mumingjiang Munisha, Juan B. Gutierrez, Scott T. Dougan
    Pages 307-381
  9. Tristan Aguero, Susannah Kassmer, Ramiro Alberio, Andrew Johnson, Mary Lou King
    Pages 383-440
  10. Maomao Zhang, Jennifer Skirkanich, Michael A. Lampson, Peter S. Klein
    Pages 441-487
  11. Petr Svoboda, Helena Fulka, Radek Malik
    Pages 489-535
  12. Francisco Pelegri, Michael Danilchik, Ann Sutherland
    Pages E1-E1
  13. Back Matter
    Pages 537-549

About this book


This book provides a comprehensive overview of topics describing the earliest steps of fertilization, from egg activation and fertilization to the activation of the zygotic genome, in various studied vertebrate model systems. The contribution of maternal and paternal factors and their role in the early embryo as parental DNA becomes modified and embryonic genes become activated is fundamental to the initiation of embryogenesis in all animal systems.  It can be argued that this is a unique developmental period, when information from the parents is compressed to direct the development of the body plan of the entire organism, a process of astounding simplicity, elegance and beauty. In addition to their fundamental scientific interest, many frontiers of biomedicine, such as reproductive biology, stem cells and reprogramming, and the understanding of intergenerational diseases, depend on advances in our knowledge of these early processes. Vertebrate Development: Maternal to Zygotic Control brings together chapters from experts in various disciplines describing the latest advances related to this important developmental transition. Each chapter is a synthesis of knowledge relevant to all vertebrates, with details on specific systems as well as comparisons between the various studied vertebrate models. The editorial expertise encompasses the fields of major vertebrate model systems (mammalian, amphibian and teleost) ensuring a balanced approach to various topics. This unique book—with its combination of in-depth and up-to-date basic research, inter-species comprehensiveness and emphasis on the very early stages of animal development—is essential for research scientists studying vertebrate development, as well as being a valuable resource for college educators teaching advanced courses in developmental biology.


cell division egg-to-embryo midblastula fertilization embryonic development

Editors and affiliations

  • Francisco Pelegri
    • 1
  • Michael Danilchik
    • 2
  • Ann Sutherland
    • 3
  1. 1.Laboratory of GeneticsUniversity of Wisconsin—MadisonMadisonUSA
  2. 2.Department of Integrative BiosciencesOregon Health & Science UniversityPortlandUSA
  3. 3.Department of Cell BiologyUniversity of Virginia Health SystemCharlottesvilleUSA

About the editors

Dr. Francisco Pelegri is currently a Professor in the Laboratory of Genetics at the University of Wisconsin-Madison. He received his PhD from the Massachusetts Institute of Technology and his postdoctoral position was at the Max Planck Institute for Developmental Biology, Tübingen, Germany. His research focus is understanding at the cellular and molecular level processes involved in early zebrafish development, specifically but not exclusively the functional diversification of cell types.

Dr. Michael V. Danilchik is a Professor in the Department of Integrative Biosciences at Oregon Health & Science University. He received his PhD from the University of Washington and did his postdoctoral training at the University of California, Berkeley. His research interest is in cellular mechanisms of pregastrular morphogenesis, particularly cytoskeletal and membrane dynamics during cleavage-stage cytokinesis, and long-range cell-cell signaling modalities involving filopodia and extracellular vesicles.

Dr. Ann E. Sutherland is an Associate Professor, Cell Biology at the School of Medicine at University of Virginia. She earned her PhD at the University of California San Francisco. Her laboratory’s research focuses primarily on the cellular mechanisms of implantation and gastrulation in the mouse embryo and, in particular, the regulation of motility in the trophoblast cells of the implanting mouse blastocyst, and the cell behaviors leading to axial elongation in the mid-gestation embryo.

Bibliographic information

  • Book Title Vertebrate Development
  • Book Subtitle Maternal to Zygotic Control
  • Editors Francisco Pelegri
    Michael Danilchik
    Ann Sutherland
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-46093-2
  • Softcover ISBN 978-3-319-83439-9
  • eBook ISBN 978-3-319-46095-6
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages X, 549
  • Number of Illustrations 10 b/w illustrations, 71 illustrations in colour
  • Topics Cell Biology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals