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© 2016

Resistance to Tyrosine Kinase Inhibitors

  • Daniele Focosi
  • The volume will provide readers with a primer on tyrosine kinase signaling and its importance in cancer

  • The reader will be first introduced to common denominators of small-molecule and antibody-derived inhibitors, and with the general phenomemon of resistance

  • Then specific reviews will focus on resistance to the most commonly used classes of tyrosine kinase inhibitors, namely BCR-ABL1, FLT3, the HER family members, angiokinase family members, ALK and the Raf/MEK/MAPK pathway

Book

Part of the Resistance to Targeted Anti-Cancer Therapeutics book series (RTACT)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Ewa Marcinkowska, Elżbieta Gocek
    Pages 1-25
  3. Giovanna Mirone, Stefania Perna, Gabriella Marfe
    Pages 27-107
  4. Sara Galimberti, Claudia Baratè, Mario Petrini, Daniele Focosi, Elena Arrigoni, Romano Danesi et al.
    Pages 109-130
  5. Timothy Ferng, Catherine Choy Smith
    Pages 131-145
  6. Francesca Simionato, Carmine Carbone, Giampaolo Tortora, Davide Melisi
    Pages 147-163
  7. Yuhui Huang
    Pages 165-178

About this book

Introduction

The volume will serve as a primer on tyrosine kinase signaling and its importance in cancer. The volume will first introduce the common denominators of small-molecule and antibody-derived inhibitors, as well as the general phenomenon of resistance. The volume will then detail resistance to the most commonly used classes of tyrosine kinase inhibitors, and will focus specific chapters on resistance to BCR-ABL1, FLT3, angiokinase family members, and ALK inhibitors.

Keywords

Cancer Cells Inhibitors Kinase Small-Molecular Inhibitors Tyrosine

Editors and affiliations

  • Daniele Focosi
    • 1
  1. 1.Pisa University HospitalPisaItaly

About the editors

Dr.Daniele Focosi was born in Lucca (Italy) in 1980. He graduated in Medicine with full grades in 2005 at the University of Pisa, and completed specialization in hematology in 2009. He achieved a Ph.D. degree in Clinical and Fundamental Virology in 2014, and a master degree in Clinical Trials in Oncology-Hematology in 2014.

He has authored 106 peer-reviewed manuscripts indexed on PubMed, for a total h-index of 16 and an overall impact factor of over 1400 points. He has been a fellow of the International Centre for Genetic Engineering and Biotechnology (ICGEB) in Trieste, and of the Collegio Ghislieri in Pavia, Italy. He is currently employed full-time at the Pisa University Hospital, where he is also a member of the Faculty of the PhD School in Clinical and Translational Sciences at University of Pisa.

He has given 37 oral and 47 poster presentations at international medical congresses, and is member of the editorial board of 17 peer-reviewed journals.

He has received awards from the European Federation of Immunogenetics, the European Society for Organ Transplantation, the Italian Society for Hematology, the Italian Interregional Transplant Association, the Italian Bone Marrow Donor Association, the Italian Society for Experimental Hematology, the Italian Society against Leukemia/Lymphoma/Myeloma.

Bibliographic information

  • Book Title Resistance to Tyrosine Kinase Inhibitors
  • Editors Daniele Focosi
  • Series Title Resistance to Targeted Anti-Cancer Therapeutics
  • Series Abbreviated Title Resistance to Targeted Anti-Cancer Therapeutics
  • DOI https://doi.org/10.1007/978-3-319-46091-8
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-46090-1
  • Softcover ISBN 978-3-319-83438-2
  • eBook ISBN 978-3-319-46091-8
  • Series ISSN 2196-5501
  • Series E-ISSN 2196-551X
  • Edition Number 1
  • Number of Pages XIII, 188
  • Number of Illustrations 2 b/w illustrations, 6 illustrations in colour
  • Topics Cancer Research
  • Buy this book on publisher's site
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