© 2017

The Blood Brain Barrier and Inflammation

  • Ruth Lyck
  • Gaby Enzmann
  • Provides a comprehensive overview on the role of the BBB during CNS inflammation

  • Covers inflammatory diseases, like autoimmune and viral induced CNS inflammation, cerebral malaria, multiple sclerosis, bacterial meningitis, and others

  • Presents methods to study neuro-inflammation, employing BBB animal models and imaging techniques


Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Norman R. Saunders, Katarzyna M. Dziegielewska, Kjeld Møllgård, Mark D. Habgood
    Pages 1-22
  3. Melanie-Jane Hannocks, Jula Huppert, Xueli Zhang, Eva Korpos, Lydia Sorokin
    Pages 49-60
  4. Patric Turowski
    Pages 81-102
  5. Victoria Makrides, Elena Dolgodilina, Daniela Virgintino
    Pages 103-151
  6. D. Roig-Carles, C. Cerutti, M. A. Lopez-Ramirez, D. Wu, David K. Male, H. E. de Vries et al.
    Pages 153-173
  7. Michael Abadier, Ruth Lyck
    Pages 187-211
  8. Philipp Agyeman, Denis Grandgirard, Stephen L. Leib
    Pages 213-252
  9. Sylvaine Guerit, Stefan Liebner
    Pages 253-277
  10. Back Matter
    Pages 279-286

About this book


Within the central nervous system (CNS) the constantly changing blood stream is separated from the CNS parenchyma by the blood brain barrier (BBB) restricting passage to selected immune cells. Under pathological conditions, however, viruses, bacteria, parasites and autoaggressive immune cells can penetrate the barrier and contribute to CNS inflammation. The BBB actively contributes to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alteration of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential for the development of new drugs to efficiently combat inflammatory diseases of the CNS. This book presents a comprehensive collection of reviews that focus on the role of the BBB. Experts in the field share their insight on structural, topological and functional properties of the BBB. They elaborate on pathophysiological changes of the inflamed BBB such as permeability, transporter proteins and alterations in microRNAs and cytokine profile. Additional chapters on multiple sclerosis and bacterial meningitis provide in depth information on significant neuroinflammatory diseases. The selection is complemented by a review on the current understanding of the BBB as signaling hub in tumor pathogenesis in the brain.


Aging Animal Models Blood Brain Barrier CNS Tumors Inflammatory Diseases of the CNS Neuro-inflammation infectious diseases

Editors and affiliations

  • Ruth Lyck
    • 1
  • Gaby Enzmann
    • 2
  1. 1.Theodor Kocher InstituteUniversity of BernBernSwitzerland
  2. 2.Theodor Kocher InstituteUniversity of BernBernSwitzerland

About the editors

Ruth Lyck (PD, PhD), group leader, Theodor-Kocher-Institute, Bern, Switzerland, works on extravasation of immune cells or metastasing cancer cells across the blood brain barrier. Gaby Enzmann (PhD), Research Associate, Theodor-Kocher-Institute, Bern, Switzerland, works on immune cell trafficking across the brain barriers into the central nervous system.

Bibliographic information

  • Book Title The Blood Brain Barrier and Inflammation
  • Editors Ruth Lyck
    Gaby Enzmann
  • Series Title Progress in Inflammation Research
  • Series Abbreviated Title Progress in Inflammation Research
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-45512-9
  • Softcover ISBN 978-3-319-83308-8
  • eBook ISBN 978-3-319-45514-3
  • Edition Number 1
  • Number of Pages VI, 286
  • Number of Illustrations 8 b/w illustrations, 24 illustrations in colour
  • Topics Immunology
    Membrane Biology
    Infectious Diseases
    Cytokines and Growth Factors
  • Buy this book on publisher's site
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