© 2017

The Immune Response to Implanted Materials and Devices

The Impact of the Immune System on the Success of an Implant

  • Bruna Corradetti

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Michelle E. Scarritt, Ricardo Londono, Stephen F. Badylak
    Pages 1-14
  3. Marta Scatena, Karen V. Eaton, Melissa F. Jackson, Susan A. Lund, Cecilia M. Giachelli
    Pages 37-62
  4. Kishor Sarkar, Yingfei Xue, Shilpa Sant
    Pages 81-105
  5. Yue Zhao, Peixiang Lan, Xian C. Li
    Pages 125-150
  6. Stephen M. Hamlet, Saso Ivanovski
    Pages 151-167
  7. Wayne Carver, Amanda M. Esch, Vennece Fowlkes, Edie C. Goldsmith
    Pages 169-188
  8. Sandra Grass, Sara Khalid Al-Ageel, Martin Hildebrandt
    Pages 223-235
  9. Back Matter
    Pages 237-241

About this book


This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy of an implant, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation plays in improving tolerance during cells and tissue transplant, in the treatment of orthopaedic, pancreatic, and hepatic diseases.The Immune Response to Implanted Materials and Devices is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration.


Biomimicry at the cellular-material interface Functional tissue restoration Host response to implant Immune evasion Immuno-modulation Innate and acquired immunity Synthetic vs natural biomaterials

Editors and affiliations

  • Bruna Corradetti
    • 1
  1. 1.Department of Life and Environmental SciencesMarche Polytechnic UniversityAnconaItaly

Bibliographic information

Industry Sectors
Chemical Manufacturing