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  • © 2017

Neuroprotective Therapy for Stroke and Ischemic Disease

  • Multifaceted discussion of stroke neuroprotection--from its history to models, research, and clinical relevance
  • Focuses on new and developing treatments, including combination therapies, for stroke disease which should be of interest to researchers and practitioners
  • Written by over 30 leading authors who are experts in their field, this compendium is selectively curated with essential information for any inquisitive student and dedicated scientist

Part of the book series: Springer Series in Translational Stroke Research (SSTSR)

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Table of contents (33 chapters)

  1. Novel Neuroprotection Mechanisms and Targets

    1. Hypothermia for Acute Ischemic Stroke

      • Roy Poblete, Gene Sung
      Pages 477-499
    2. Modern Endovascular Treatment of Ischemic Disease

      • Steven L. Gogela, Todd A. Abruzzo, Mario Zuccarello
      Pages 501-526
    3. Cerebral Microbleeds and Thrombolysis for Acute Ischemic Stroke

      • JungSeok Lee, Mark Fisher
      Pages 527-536
    4. Targeting Pericytes and the Microcirculation for Ischemic Stroke Therapy

      • Ain A. Neuhaus, Brad A. Sutherland, Alastair M. Buchan
      Pages 537-556
  2. Thrombolysis and Embolectomy

    1. Front Matter

      Pages 557-557
    2. Thrombolytic and Endovascular Therapies for Acute Ischemic Stroke

      • Hormozd Bozorgchami, Helmi L. Lutsep
      Pages 559-591
    3. Sonothrombolysis for Acute Ischemic Stroke: A Critical Appraisal

      • Georgios Tsivgoulis, Apostolos Safouris, Andrei V. Alexandrov
      Pages 593-606
    4. Combination Therapy with Thrombolysis

      • Burak Yulug, Wolf-Rüdiger Schäbitz
      Pages 607-620
    5. Oxygen Carriers: Are They Enough for Cellular Support?

      • Jennifer L. H. Johnson
      Pages 621-640
    6. A New Paradigm in Protecting Ischemic Brain: Preserving the Neurovascular Unit Before Reperfusion

      • Natacha Le Moan, Philberta Y. Leung, Natalia Rost, Jonathan A. Winger, Ana Krtolica, Stephen P. Cary
      Pages 641-664
  3. Stroke Models and Clinical Trial Considerations

    1. Front Matter

      Pages 665-665
    2. Rabbit Spinal Cord Ischemia Model for the Development of Neuroprotective Treatments

      • Daisy Chou, Anja Muehle, Paul A. Lapchak, Ali Khoynezhad
      Pages 689-700
    3. Stroke Sex Differences: From Basic Research to Clinical Trials

      • Claire L. Gibson, Philip M. W. Bath, Raeed Altaee
      Pages 701-709
    4. Unpuzzling the Comorbid Type 2 Diabetes and Hypertension-Related Cognitive Dysfunction and Stroke

      • I. Sebastião, E. Candeias, M. S. Santos, C. R. Oliveira, Paula I. Moreira, Ana I. Duarte
      Pages 711-731
    5. Sex-Specific Factors in Stroke

      • Anjali Chauhan, Hope Moser, Louise D. McCullough
      Pages 733-750
  4. Back Matter

    Pages 775-795

About this book

A critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in academia and industry, to address new ways to provide effective treatment to victims of ischemic and hemorrhagic stroke and other ischemic diseases. Currently stroke can be successfully treated through the administration of a thrombolytic, but the therapeutic window is short and many patients are not able to receive treatment. Only about 30% of patients are "cured" by available treatments. In 5 sections, the proposed volume will explore historical and novel neuroprotection mechanisms and targets, new and combination therapies, as well as clinical trial design for some of the recent bench-side research.

Editors and Affiliations

  • Department of Neurology and Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, USA

    Paul A. Lapchak

  • Loma Linda University School of Medicine, Loma Linda, USA

    John H. Zhang

About the editors

Paul Lapchak is the director of translational neurodegenerative disease research at Cedars-Sinai Medical Center in California. Dr. Lapchak obtained his Ph.D. at McGill University and University of Southern California. His lab focuses on developing new therapeutic approaches to treat different types of stroke as well as experimenting with neuroprotective agents. In addition, his research extends to drug development using the rabbit embolic stroke model and multiple assay methods. Dr. Lapchak is editor-in-chief of the Journal of Neurology & Neurophysiology and associate editor of the journal Translational Stroke Research. With over twenty years of experience and numerous publications, Dr. Lapchak is a leading expert in his field of translational stroke research.

John Zhang is doctor and professor in the departments of Anesthesiology, Neurosurgery, Neurology, and Physiology at the Loma Linda University School of Medicine in California. He obtained his Ph.D. at the University of Alberta, Canada and his MD at Chongqing University of Medical Sciences, China. His lab focuses on hemorrhagic and ischemic stroke, specifically on cerebral vascular biology, neuroprotection, gene therapy, signaling pathways, and apoptosis. Dr. Zhang is on the editorial boards of the journals Surgical Neurology and Neurological Research. Coauthor of countless publications, Dr. Zhang is also a member of several professional societies and participates in current discussions of stroke disease research and neuroprotection.

Bibliographic Information

  • Book Title: Neuroprotective Therapy for Stroke and Ischemic Disease

  • Editors: Paul A. Lapchak, John H. Zhang

  • Series Title: Springer Series in Translational Stroke Research

  • DOI: https://doi.org/10.1007/978-3-319-45345-3

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2017

  • Hardcover ISBN: 978-3-319-45344-6Published: 19 January 2017

  • Softcover ISBN: 978-3-319-83272-2Published: 17 July 2018

  • eBook ISBN: 978-3-319-45345-3Published: 12 January 2017

  • Series ISSN: 2363-958X

  • Series E-ISSN: 2363-9598

  • Edition Number: 1

  • Number of Pages: XVII, 795

  • Number of Illustrations: 34 b/w illustrations, 71 illustrations in colour

  • Topics: Neurosciences, Cardiology

  • Industry Sectors: Biotechnology, Consumer Packaged Goods, Health & Hospitals, Pharma

Buy it now

Buying options

eBook USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access