© 2017

Neuroprotective Therapy for Stroke and Ischemic Disease

  • Paul A. Lapchak
  • John H. Zhang

Part of the Springer Series in Translational Stroke Research book series (SSTSR)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Stroke Neuroprotection: The History and Learning Experience

    1. Front Matter
      Pages 1-1
    2. Sarah K. McCann, Emily S. Sena, Gillian L. Currie, Malcolm R. Macleod, David W. Howells
      Pages 73-93
    3. Donald J. DeGracia, Doaa Taha, Fika Tri Anggraini, Zhifeng Huang
      Pages 95-122
    4. Victoria E. O’Collins
      Pages 123-131
    5. Ali Razmara, Steven C. Cramer
      Pages 133-154
  3. Novel Neuroprotection Mechanisms and Targets

    1. Front Matter
      Pages 155-155
    2. Linda M. Haugaard-Kedström, Eduardo F. A. Fernandes, Kristian Strømgaard
      Pages 157-184
    3. Anders Bach
      Pages 203-250
    4. Alejandro Escobar-Peso, Mourad Chioua, Valerio Frezza, Emma Martínez-Alonso, José Marco-Contelles, Alberto Alcázar
      Pages 251-283
    5. Diana Amantea, Rosaria Greco, Cristina Tassorelli, Giacinto Bagetta
      Pages 303-328
    6. Morgane Louessard, Eloise Lemarchand, Carine Ali, Denis Vivien, Benoit Denis Roussel
      Pages 329-348
    7. Roberto Federico Villa, Federica Ferrari, Antonio Moretti
      Pages 349-399
    8. Sergio Amaro, Xabier Urra, Ángel Chamorro
      Pages 401-414
    9. Hong-Shuo Sun, Zhong-Ping Feng
      Pages 415-432
    10. Victor V. Uteshev
      Pages 433-457

About this book


This book is a critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in both academia and industry; it serves to address new ways to provide effective treatment to victims of ischemic and hemorrhagic stroke and other ischemic diseases. Currently, stroke can be successfully treated through the administration of a thrombolytic, but the therapeutic window is short and many patients are not able to receive treatment. Only about 30% of patients are "cured" by available treatments. Divided into five sections, the proposed volume explores historical and novel neuroprotection mechanisms and targets, new and combination therapies, as well as clinical trial design for some of the most recent bench-side research.


CNS disorders thrombolysis oxidative stress excitotoxicity sex-specific

Editors and affiliations

  • Paul A. Lapchak
    • 1
  • John H. Zhang
    • 2
  1. 1.Department of Neurology and NeurosurgeryCedars-Sinai Medical CenterLos AngelesUSA
  2. 2.Loma Linda University School of MedicineLoma LindaUSA

About the editors

Paul Lapchak is the director of translational neurodegenerative disease research at Cedars-Sinai Medical Center in California. Dr. Lapchak obtained his Ph.D. at McGill University and University of Southern California. His lab focuses on developing new therapeutic approaches to treat different types of stroke as well as experimenting with neuroprotective agents. In addition, his research extends to drug development using the rabbit embolic stroke model and multiple assay methods. Dr. Lapchak is editor-in-chief of the Journal of Neurology & Neurophysiology and associate editor of the journal Translational Stroke Research. With over twenty years of experience and numerous publications, Dr. Lapchak is a leading expert in his field of translational stroke research.

John Zhang is doctor and professor in the departments of Anesthesiology, Neurosurgery, Neurology, and Physiology at the Loma Linda University School of Medicine in California. He obtained his Ph.D. at the University of Alberta, Canada and his MD at Chongqing University of Medical Sciences, China. His lab focuses on hemorrhagic and ischemic stroke, specifically on cerebral vascular biology, neuroprotection, gene therapy, signaling pathways, and apoptosis. Dr. Zhang is on the editorial boards of the journals Surgical Neurology and Neurological Research. Coauthor of countless publications, Dr. Zhang is also a member of several professional societies and participates in current discussions of stroke disease research and neuroprotection.

Bibliographic information

  • Book Title Neuroprotective Therapy for Stroke and Ischemic Disease
  • Editors Paul A. Lapchak
    John H. Zhang
  • Series Title Springer Series in Translational Stroke Research
  • Series Abbreviated Title Springer Ser.Translations
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-45344-6
  • Softcover ISBN 978-3-319-83272-2
  • eBook ISBN 978-3-319-45345-3
  • Series ISSN 2363-958X
  • Series E-ISSN 2363-9598
  • Edition Number 1
  • Number of Pages XVII, 795
  • Number of Illustrations 34 b/w illustrations, 71 illustrations in colour
  • Topics Neurosciences
  • Buy this book on publisher's site
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