© 2017

Signaling-Mediated Control of Cell Division

From Oogenesis to Oocyte-to-Embryo Development

  • Swathi Arur


  • State-of-the-art summary on the important role of germ cells to life

  • Gives profound information on the molecular and signaling events that control germ cells formation and maintenance

  • Explains the mechanisms that regulate oocyte fitness and quality in humans and vertebrates


Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 59)

Table of contents

  1. Front Matter
    Pages i-x
  2. Pooja Flora, Alicia McCarthy, Maitreyi Upadhyay, Prashanth Rangan
    Pages 1-30
  3. Kaitlin M. Laws, Daniela Drummond-Barbosa
    Pages 67-99
  4. Rachel Reichman, Benjamin Alleva, Sarit Smolikove
    Pages 125-173
  5. Kumari Pushpa, Ganga Anil Kumar, Kuppuswamy Subramaniam
    Pages 175-200
  6. Ewa Borsuk, Joanna Jachowicz, Malgorzata Kloc, Jean-Pierre Tassan, Jacek Z. Kubiak
    Pages 201-211
  7. Marc Yeste, Celine Jones, Siti Nornadhirah Amdani, Kevin Coward
    Pages 213-239
  8. Hieu D. Hoang, Michael A. Miller
    Pages 241-267
  9. Back Matter
    Pages 287-292

About this book


This volume covers the current knowledge base on the role of signaling and environmental pathways that control the normal development of germline stem cells, meiotic progression of oocytes, events of oocyte maturation and fertilization, and the birth of an embryo.

Germ cells are uniquely poised to sustain life across generations through the fusion of oocyte and sperm. Because of the central importance of germ cells to life, much work has been dedicated to obtaining a clear understanding of the molecular and signaling events that control their formation and maintenance. Germ cells are set aside from somatic cells in the embryo and go through specialized meiotic cell cycles as the animal matures. These cell cycles are interspersed with long periods of arrest. In human females, meiosis I is initiated in the fetus. At birth, oocytes are arrested in meiosis I; after puberty, every month an oocyte initiates meiosis II – ovulation. Upon sperm availability these cells are fertilized, generate an embryo, and the cycle-of-life continues. During meiotic I progression and arrest, the fitness of oocytes and their progeny are likely influenced by environmental cues and signaling pathways.

A lot of recent work has focused on understanding the mechanisms that regulate oocyte fitness and quality in humans and vertebrates. Much of our understanding on the events of meiosis I and germline stem cell populations comes from work in invertebrates, wherein the germline stem cells produce oocytes continuously through adult development. In both inverbrates and vertebrates nutritional and signaling pathways control the regulation of stem cells in such a manner so as to couple production of gametes with the nutritional availability. Additionally, mature oocytes arrest both in meiosis I and meiosis II, and signaling and nutritional pathways have been shown to regulate their formation, and maintenance, such that despite long periods of arrest, the oocyte quality is assured and errors in chromosome segregation and varied cytoplasmic events are minimal.


Germ Cells Germline Stem Cells Oocytes Oogenesis Embryo Development

Editors and affiliations

  • Swathi Arur
    • 1
  1. 1.Dept. of Genetics, Genes & Dev. ProgramUT MD Anderson Cancer CenterHoustonUSA

Bibliographic information

  • Book Title Signaling-Mediated Control of Cell Division
  • Book Subtitle From Oogenesis to Oocyte-to-Embryo Development
  • Editors Swathi Arur
  • Series Title Results and Problems in Cell Differentiation
  • Series Abbreviated Title Results Cell Differentiation
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-44819-0
  • Softcover ISBN 978-3-319-83143-5
  • eBook ISBN 978-3-319-44820-6
  • Series ISSN 0080-1844
  • Series E-ISSN 1861-0412
  • Edition Number 1
  • Number of Pages X, 292
  • Number of Illustrations 3 b/w illustrations, 34 illustrations in colour
  • Topics Embryology
    Cell Cycle Analysis
    Stem Cells
    Gene Expression
    Cell Physiology
  • Buy this book on publisher's site