© 2017

Ageing: Lessons from C. elegans

  • Anders Olsen
  • Matthew S. Gill

Part of the Healthy Ageing and Longevity book series (HAL)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Anders Olsen, Matthew S. Gill
    Pages 1-7
  3. Laura A. Herndon, Catherine A. Wolkow, Monica Driscoll, David H. Hall
    Pages 9-39
  4. Pedro Reis-Rodrigues, Kailiang Jia, Matthew S. Gill
    Pages 41-62
  5. Seon Woo A. An, Murat Artan, Sangsoon Park, Ozlem Altintas, Seung-Jae V. Lee
    Pages 63-81
  6. Alfonso Schiavi, Natascia Ventura
    Pages 83-108
  7. Francis R. G. Amrit, Arjumand Ghazi
    Pages 109-135
  8. Cheng Shi, Coleen T. Murphy
    Pages 137-162
  9. Claire Bénard, Maria Doitsidou
    Pages 163-189
  10. Dana L. Miller, Joseph Horsman, Frazer I. Heinis
    Pages 191-217
  11. Bart P. Braeckman, Patricia Back, Filip Matthijssens
    Pages 219-244
  12. Aditi U. Gurkar, Matthew S. Gill, Laura J. Niedernhofer
    Pages 245-264
  13. Silvestre Alavez
    Pages 265-283
  14. Jarod Rollins, Aric Rogers
    Pages 285-305
  15. Jonathon Duffy, Ayse Sena Mutlu, Meng C. Wang
    Pages 307-329
  16. Malene Hansen
    Pages 331-354
  17. Yue Zhang, William B. Mair
    Pages 355-391
  18. Dana A. Lynn, Sean P. Curran
    Pages 393-409
  19. Katrine V. Christensen, Maria G. Morch, Tine H. Morthorst, Simon Lykkemark, Anders Olsen
    Pages 411-429
  20. Gordon J. Lithgow
    Pages 431-435

About this book


This book brings together in one volume the current state of ageing research in the nematode Caenorhabditis elegans. The authors are leading researchers in the field, placing this topic in the context of human ageing, describing how and why basic discoveries in this simple organism have impacted our prospects for intervention in the ageing process. The authors cover a broad range of topics with regards to organismal and reproductive ageing including anatomical, physiological and biochemical changes, as well as genetic and environmental interventions that promote longevity and ameliorate age-related disease. Ageing is the single most important factor determining the onset of human disease in developed countries. With current worldwide demographic trends indicating that the number of individuals over the age of 65 will continue to rise, it is clear that an understanding of the processes that underpin ageing and age-related disease represents a key challenge in the biomedical sciences. In recent years there have been huge advances in our understanding of the ageing process and many of these have stemmed from genetic analysis of C. elegans.

With no analogous book in this subject area this work will be of interest to a wide audience, ranging from academic researchers to the general public.


Ageing Caenorhabditis elegans Healthspan Life extension Longevity-associated genes

Editors and affiliations

  • Anders Olsen
    • 1
  • Matthew S. Gill
    • 2
  1. 1.Department of Molecular Biology and GeneticsAarhus UniversityAarhusDenmark
  2. 2.Department of Metabolics & AgingThe Scripps Research Institute - Scripps FloridaJupiterUSA

Bibliographic information

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