© 2016

DNA Methyltransferases - Role and Function

  • Albert Jeltsch
  • Renata Z. Jurkowska
  • Offers comprehensive insights into the newest findings in the field of DNA methylation

  • Provides in depth knowledge on the structure, enzymatic mechanism as well as the biological roles of DNA methyltransferases

  • Discusses related processes like reading of DNA methylation and DNA demethylation

  • Broadens the understanding on the role of DNA methyltransferases in human diseases

  • Chapters written by leading experts in the field


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 945)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Yuri Motorin, Salifu Seidu-Larry, Mark Helm
    Pages 19-33
  3. Josep Casadesús
    Pages 35-61
  4. Shoji Tajima, Isao Suetake, Kohei Takeshita, Atsushi Nakagawa, Hironobu Kimura
    Pages 63-86
  5. Renata Z. Jurkowska, Albert Jeltsch
    Pages 87-122
  6. Jiameng Dan, Taiping Chen
    Pages 123-150
  7. Ranjani Lakshminarasimhan, Gangning Liang
    Pages 151-172
  8. Zach Klapholz O’Brown, Eric Lieberman Greer
    Pages 213-246
  9. Wendy Dean
    Pages 247-274
  10. Xiaotong Yin, Yanhui Xu
    Pages 275-302
  11. Takashi Shimbo, Paul A. Wade
    Pages 303-320
  12. Marie Lopez, Ludovic Halby, Paola B. Arimondo
    Pages 431-473
  13. Sabine Stolzenburg, Désirée Goubert, Marianne G. Rots
    Pages 475-490
  14. Paola Laurino, Liat Rockah-Shmuel, Dan S. Tawfik
    Pages 491-509
  15. Miglė Tomkuvienė, Edita Kriukienė, Saulius Klimašauskas
    Pages 511-535

About this book


DNA methyltransferases are important enzymes in a broad range of organisms. Dysfunction of DNA methyltransferases in humans leads to many severe diseases, including cancer. This book focuses on the biochemical properties of these enzymes, describing their structures and mechanisms in bacteria, humans and other species, including plants, and also explains the biological processes of reading of DNA methylation and DNA demethylation. It covers many emerging aspects of the biological roles of DNA methylation functioning as an essential epigenetic mark and describes the role of DNA methylation in diseases. Moreover, the book explains modern technologies, like targeted rewriting of DNA methylation by designed DNA methyltransferases, as well as technological applications of DNA methyltransferases in DNA labelling. Finally, the book summarizes recent methods for the analysis of DNA methylation in human DNA. Overall, this book represents a comprehensive state-of-the-art- work and is a must-have for advanced researchers in the field of DNA methylation and epigenetics.


DNA methylation Epigenetics Methyltransferase Demethylation DNA labelling Cancer Therapeutic targets control of gene expression Chromatin Genome imprinting Epigenetic editing Cellular memory Biomarkers Reader proteins Emerging technologies

Editors and affiliations

  • Albert Jeltsch
    • 1
  • Renata Z. Jurkowska
    • 2
  1. 1.Institut für BiochemieUniversität StuttgartStuttgartGermany
  2. 2.BioMed X Innovation CenterHeidelbergGermany

About the editors

Albert Jeltsch is Pofessor for Biochemistry at the University of Stuttgart, Germany.

Renata Jurkowska is Group Leader in Biochemistry and Molecular Epigenetics at the University of Stuttgart, Germany.

Bibliographic information

  • Book Title DNA Methyltransferases - Role and Function
  • Editors Albert Jeltsch
    Renata Z. Jurkowska
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-43622-7
  • Softcover ISBN 978-3-319-82870-1
  • eBook ISBN 978-3-319-43624-1
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages VIII, 535
  • Number of Illustrations 4 b/w illustrations, 57 illustrations in colour
  • Topics Cell Biology
    Gene Expression
  • Buy this book on publisher's site
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