Salivary Gland Development and Regeneration

Advances in Research and Clinical Approaches to Functional Restoration

  • Seunghee Cha

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Updates on Salivary Gland Development

    1. Front Matter
      Pages 1-1
    2. Melinda Larsen, Petko Bogdanov, Ravi Sood, Hae Ryong Kwon, Deirdre A. Nelson, Connor Duffy et al.
      Pages 23-44
    3. Isabel Castro, María-José Barrera, Sergio González, Sergio Aguilera, Ulises Urzúa, Juan Cortés et al.
      Pages 45-71
  3. Glandular Damage and Cell Replacement Therapy

  4. Bioengineering of Salivary Glands

    1. Front Matter
      Pages 131-131
    2. Mariane Martinez, Danielle Wu, Mary C. Farach-Carson, Daniel A. Harrington
      Pages 145-171
    3. Jong Woo Choi, Namkug Kim, Chang Mo Hwang
      Pages 173-191
  5. Therapeutic Considerations for Restoration of Salivary Function

    1. Front Matter
      Pages 205-205
    2. Guy Carpenter, Polliane Carvalho
      Pages 207-215
    3. Varun V. Varadarajan, Peter T. Dziegielewski
      Pages 229-263

About this book


This book provides a comprehensive update on the latest information and knowledge which emerged from translational and basic science research endeavors, targeting the regeneration of salivary glands. The coverage includes salivary gland growth and development, stem cell therapy, bioengineering of salivary glands, and perspectives on and practical approaches to restoration of secretory function. More specifically, among the individual topics addressed are the various types of stem cell of value for cell replacement therapy, technological advances with respect to 3D printing, gene therapy, organ culture of salivary glands, and surgical aspects of the feasibility and practicality of transplantation. Readers will find helpful practical guidance on functional restorations of damaged salivary glands and stimulating insights into potential future directions in salivary gland regeneration research. The authors are all acknowledged experts from a range of academic and clinical backgrounds. Accordingly, the book will be of interest not only to clinicians, such as general dental practitioners, oral medicine specialists, and surgeons who manage dry mouth patients, but also to biomedical engineers, stem cell researchers, and transplant surgeons.


Cell replacement therapy Sjӧgren’s syndrome (SjS) Stem cell therapy Gene therapy Tissue engineering 3D organ culture 3D printing Transplantation Regenerative medicine Surgical management of salivary gland disease Saliva secretion Systems biology Mucin Adult stem cells Transcription factors Matrix biology Organ germ

Editors and affiliations

  • Seunghee Cha
    • 1
  1. 1.Oral and Maxillofacial Diagnostic SciencesUniversity of FloridaGainesvilleUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-43511-4
  • Online ISBN 978-3-319-43513-8
  • Buy this book on publisher's site
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