Imaging Biomarkers

Development and Clinical Integration

  • Luis Martí-Bonmatí
  • Angel Alberich-Bayarri

Table of contents

  1. Front Matter
    Pages i-viii
  2. Fabian Bamberg, Mike Notohamiprodjo, Ulrich Kramer, Marius Horger, Konstantin Nikolaou
    Pages 29-43
  3. Javier Sánchez-González, Paula Montesinos
    Pages 45-52
  4. José V. Manjón
    Pages 53-63
  5. Angel Alberich-Bayarri
    Pages 65-69
  6. George C. Manikis, Eleftherios Kontopodis, Katerina Nikiforaki, Konstantinos Marias, Nickolas Papanikolaou
    Pages 71-86
  7. Bernard E. Van Beers, Benjamin Leporq, Sabrina Doblas, Philippe Garteiser
    Pages 87-99
  8. George C. Manikis, Nickolas Papanikolaou, Celso Matos
    Pages 115-122
  9. Enrique Ruiz-Martinez, Jose Damian Segrelles Quilis, Fabio García Castro, Luis Martí-Bonmatí, Ángel Alberich-Bayarri
    Pages 123-138
  10. David J. Lomas, Edmund Godfrey
    Pages 139-152
  11. Annalisa Mantarro, Paola Scalise, Emanuele Neri
    Pages 153-157
  12. Angel Alberich-Bayarri, Enrique Ruiz Martínez, Rafael Hernández Navarro, José Tomás Cucarella, Fabio García Castro
    Pages 159-167
  13. Diana M. Sima, Dirk Loeckx, Dirk Smeets, Saurabh Jain, Paul M. Parizel, Wim Van Hecke
    Pages 169-180
  14. Elies Fuster-Garcia, Juan Miguel García-Gómez, Elena De Angelis, Arthur Sraum, Arthur Molnar, Sabine Van Huffel et al.
    Pages 181-194
  15. M. A. Marino, K. Pinker, P. Baltzer, T. H. Helbich
    Pages 195-251
  16. Jean-Paul Vallée, David Carballo
    Pages 253-258
  17. Manuela França, Ángel Alberich-Bayarri, Luis Martí-Bonmatí
    Pages 279-294
  18. Yan Liu, John C. Waterton
    Pages 295-306
  19. Back Matter
    Pages 307-316

About this book


This is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imaging can serve as a powerful quantification instrument capable of providing valuable information on organ and tissue properties. The process of imaging biomarker development is considered step by step, covering proof of concept, proof of mechanism, image acquisition, image preparation, imaging biomarker analysis and measurement, detection of measurement biases (proof of principle), proof of efficacy and effectiveness, and reporting of results. Sources of uncertainty in the accuracy and precision of measurements and pearls and pitfalls in gold standards and biological correlation are discussed. In addition, practical use cases are included on imaging biomarker implementation in brain, oncologic, cardiovascular, musculoskeletal, and abdominal diseases. The authors are a multidisciplinary team of expert radiologists and engineers, and the book will be of value to all with an interest in the quantitative imaging of biomarkers in personalized medicine.


Biomedical Engineering Image Processing Imaging Biomarker Development Imaging Biomarkers Measurements Multi-variate analysis Parametric Images Quantitative Radiology Precision Medicine in Imaging Imaging Biobanks

Editors and affiliations

  • Luis Martí-Bonmatí
    • 1
  • Angel Alberich-Bayarri
    • 2
  1. 1.La Fe University and Polithecnic HospitalUniversity of ValenciaValenciaSpain
  2. 2.La Fe University and Polithecnic HospitalUniversity of ValenciaValenciaSpain

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-43502-2
  • Online ISBN 978-3-319-43504-6
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals