© 2017

Molecular Genetics of Endometrial Carcinoma

  • Lora Hedrick Ellenson
  • Explains the metabolic and hormonal influences of endometrial carcinoma

  • Gives perspectives on traditional approaches and next-generation sequencing in the molecular profiling of endometrial carcinoma

  • Reviews several signaling pathways and mouse models used to study cancer proliferation


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 943)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Ashley S. Felix, Hannah P. Yang, Daphne W. Bell, Mark E. Sherman
      Pages 3-46
    3. Sigurd F. Lax
      Pages 75-96
  3. Molecular Profiling

    1. Front Matter
      Pages 97-97
    2. Christopher J. Walker, Paul J. Goodfellow
      Pages 99-118
    3. Matthieu Le Gallo, Fred Lozy, Daphne W. Bell
      Pages 119-148
    4. Nuria Eritja, Andree Yeramian, Bo-Juen Chen, David Llobet-Navas, Eugenia Ortega, Eva Colas et al.
      Pages 149-207
  4. Mouse Models

    1. Front Matter
      Pages 209-209
    2. Christopher G. Peña, Diego H. Castrillón
      Pages 211-241
    3. Tae Hoon Kim, Jung-Yoon Yoo, Jae-Wook Jeong
      Pages 243-259
    4. Ayesha Joshi, Lora Hedrick Ellenson
      Pages 261-273
  5. Back Matter
    Pages 275-281

About this book


This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma.  These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.


PTEN/ PI3K endometrial cancer next generation sequencing signaling pathways molecular genetics

Editors and affiliations

  • Lora Hedrick Ellenson
    • 1
  1. 1.Department of Pathology and Laboratory MedicineWeill Cornell MedicineNew YorkUSA

About the editors

Dr. Lora Hedrick Ellenson is Professor of Pathology and Laboratory Medicine and Director of the Division of Gynecological Pathology at Weill Cornell Medicine. She has a national reputation for her expertise in endometrial carcinoma. Dr. Ellenson’s research interest is primarily focused on the molecular genetics and pathology of endometrial carcinoma, the most common malignancy of the female genital tract. In addition to satisfying her clinical duties, Dr. Ellenson oversees an NIH funded research program to develop genetic mouse models of endometrial tumorigenesis in addition to defining the differences, and similarities, in the molecular genetic alterations in the two major types of endometrial carcinoma. She has over 80 publications on the topic with over 3,430 citations.

Bibliographic information

  • Book Title Molecular Genetics of Endometrial Carcinoma
  • Editors Lora Hedrick Ellenson
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-43137-6
  • Softcover ISBN 978-3-319-82747-6
  • eBook ISBN 978-3-319-43139-0
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XI, 281
  • Number of Illustrations 1 b/w illustrations, 31 illustrations in colour
  • Topics Cancer Research
    Gene Expression
  • Buy this book on publisher's site
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