Molecular Allergy Diagnostics

Innovation for a Better Patient Management

  • Jörg Kleine-Tebbe
  • Thilo Jakob

Table of contents

  1. Front Matter
    Pages i-xx
  2. Protein Families and Relationships

    1. Front Matter
      Pages 1-1
    2. J. Kleine-Tebbe, M. Ollert, C. Radauer, T. Jakob
      Pages 3-19
    3. J. Kleine-Tebbe, B. K. Ballmer-Weber, H. Breiteneder, S. Vieths
      Pages 21-42
    4. M. Wallner, F. Ferreira, H. Hofer, M. Hauser, V. Mahler, J. Kleine-Tebbe
      Pages 43-56
    5. A. Petersen, J. Kleine-Tebbe, S. Scheurer
      Pages 57-75
    6. C. Radauer, J. Kleine-Tebbe, K. Beyer
      Pages 77-90
  3. Test Systems, Singleplex Analysis and Multiplex Analysis

    1. Front Matter
      Pages 109-109
    2. T. Jakob, P. Forstenlechner, P. M. Matricardi, J. Kleine-Tebbe
      Pages 169-200
  4. Marker Allergens

    1. Front Matter
      Pages 201-201
    2. K. Gangl, V. Niederberger, J. M. Davies, R. Valenta, A. Nandy
      Pages 203-226
    3. L. Lange, K. Beyer, J. Kleine-Tebbe
      Pages 241-256
    4. L. Lange, K. Beyer, J. Kleine-Tebbe
      Pages 257-269
    5. B. K. Ballmer-Weber, K. Hoffmann-Sommergruber
      Pages 271-289
    6. C. Hilger, W. Hemmer, I. Swoboda, M. Morisset, J. Fischer, A. Tripathi et al.
      Pages 305-326
    7. C. Hilger, J. Kleine-Tebbe, M. van Hage
      Pages 363-379
    8. A. Kuehn, C. Radauer, A. L. Lopata, J. Kleine-Tebbe, I. Swoboda
      Pages 381-397
    9. A. L. Lopata, J. Kleine-Tebbe, S. D. Kamath
      Pages 399-414
    10. S. Vrtala, S. Kull, J. Kleine-Tebbe
      Pages 415-428
    11. C. Hilger, A. Kuehn, M. Raulf, A. Pomés, T. Jakob
      Pages 429-444
  5. Designer Allergens, Hypoallergens and Fusion Allergens

    1. Front Matter
      Pages 471-471
    2. A. Nandy, P. S. Creticos, D. Häfner
      Pages 473-486
    3. V. Mahler, R. E. Goodman
      Pages 487-511
  6. Back Matter
    Pages 513-531

About this book


This book, based on a recent German publication, offers an overview of basic data and recent developments in the groundbreaking field of molecular allergology. It comprehensively explores the origin and structure of single allergen molecules ("components") and their utility in improving the management of type I, IgE-mediated allergic reactions and disorders like allergic respiratory diseases, food allergies, and anaphylaxis.

Highly specific testing, called component-resolved diagnostics, aims to identify and utilize single molecules. Over 200 single allergens from plant or animal sources have been applied to single or multiplex laboratory testing for the presence of allergen-specific IgE. This leap in assay sensitivity and specificity has led to three major advances in patient management: discrimination between primary allergic sensitization and complex cross-reactivity, recognition of IgE profiles for certain allergens and identification of patients most likely to benefit from allergen-specific immunotherapy.

The book discusses in detail the benefits and limitations of this 21st century technology, and offers suggestions for the use of molecular allergology in routine clinical practice. It is a “must read” for physicians treating allergic patients as well as scientists interested in natural allergic molecules and their interactions with the human immune system.


Allergen Anaphylaxis Immunoglobulin E IgE Component Resolved Diagnostics Personalized medicine

Editors and affiliations

  • Jörg Kleine-Tebbe
    • 1
  • Thilo Jakob
    • 2
  1. 1.Professor of Dermatology and AllergologyAllergy and Asthma Center Westend Outpatient Clinic Hanf, Ackermann and Kleine-TebbeBerlinGermany
  2. 2.Professor of Dermatology and Allergology Chairman of the Department of Dermatology and AllergologyUniversity Medical Center Gießen and Marburg Campus Gießen Justus Liebig University GießenGießenGermany

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-42498-9
  • Online ISBN 978-3-319-42499-6
  • Buy this book on publisher's site