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Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases

  • Paola┬áMina-Osorio

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Diagnosis, Patient Stratification and Biomarkers

    1. Front Matter
      Pages 1-1
    2. Michael D. Lockshin
      Pages 3-13
    3. Gregory J. Dennis, Gonzalo Fernandez, Heather Iocca, Holly Hilton
      Pages 15-33
  3. Genomic Medicine

    1. Front Matter
      Pages 51-51
  4. Bispecific Antibodies

    1. Front Matter
      Pages 73-73
    2. Alain C. Tissot, Ulrich Brinkmann
      Pages 75-97
  5. Cross-Functional Targets

    1. Front Matter
      Pages 99-99
    2. Angelo Corti, Martina Fiocchi, Flavio Curnis
      Pages 101-122
    3. Mary-Ellen Costello, Matthew A. Brown
      Pages 145-165
    4. Patrick S. C. Leung, Zongwen Shuai, Bin Liu, Shang An Shu, Lingyun Sun
      Pages 167-198
  6. Back Matter
    Pages 199-202

About this book

Introduction

As our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is different in different patient subsets.

Promising new technologies have been conceived that address the hypotheses that targeting multiple pathways simultaneously, selectively delivering therapeutics to areas of inflammation and/or resetting the immune system, could take efficacy to new levels. However, we have long waited for the arrival of some of these technologies to the bedside, or even far enough in the drug development process in spite of the initial enthusiasm. Some of the examples covered in this book include bispecific antibodies and genomic medicines, microparticles and targeted delivery of drugs to inflamed vasculature.

Most published reviews and book chapters on novel therapies for inflammatory diseases describe positive attributes of molecules or technologies under investigation and the rationale for developing them into therapeutics. The originality and potential value of this book is not in the description of these targets or technologies from the point of view of their structure or mechanism of action exclusively, but rather, in making an effort to critically address the question of what is needed to move these technologies into the clinic. Has the technology not made it past the preclinical stage and why? Has it already been tested in humans and failed? What are the potential reasons behind those failures? What do experts in each field believe can be done better to increase the probabilities of success?

In addition, the authors address the competitive landscape and summarize clinical studies that have failed in the respective area. They talk about the patient populations that would be required for the successful conduction of a clinical trial to test certain molecules, and they proactively share their views regarding both the potential and the drawbacks of targets or methodologies.


Keywords

drug development chronic inflammation immunosuppressive microvesicles genomic-based therapies bi-specific antibodies metabolic targets

Editors and affiliations

  • Paola┬áMina-Osorio
    • 1
  1. 1.US Medical DivisionEli Lilly & CompanyNew YorkUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-42252-7
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-42251-0
  • Online ISBN 978-3-319-42252-7
  • Buy this book on publisher's site
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