© 2016

Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy

  • Emmanuel Donnadieu


  • Gives the latest research on specific defects in T cell trafficking, which hinder the success of cancer immunotherapy

  • Provides the basic priniciples to T cell migration during efficient immune responses

  • Explores therapeutic interventions to promote T cell migration into tumors


Part of the Resistance to Targeted Anti-Cancer Therapeutics book series (RTACT, volume 9)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Jens V. Stein, Federica Moalli, Markus Ackerknecht
    Pages 1-19
  3. Pierre-Louis Loyher, Christophe Combadière, Alexandre Boissonnas
    Pages 21-49
  4. Kellsye L. Fabian, Walter J. Storkus
    Pages 51-76
  5. Bertrand Dubois, Hélène Kaplon, Coline Couillault, Christophe Caux, Marie-Caroline Dieu-Nosjean
    Pages 99-125
  6. Stefano Garetto, Claudia Sardi, Diego Morone, Marinos Kallikourdis
    Pages 163-177
  7. Back Matter
    Pages 195-199

About this book


This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.

The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.


Cancer Treatment Anti-tumor immune response Immogenic tumors Cancer-associated fibroblasts Cancer-associated Tertiary Lymphoid Structures Cancer immunotherapy Chemokines Chimeric antigen receptor

Editors and affiliations

  • Emmanuel Donnadieu
    • 1
  1. 1.Institut Cochin INSERM, Université Paris DescartesParisFrance

About the editors

Emmanuel Donnadieu, Ph.D, is a researcher and team leader of the 'Dynamics of T cell Interactions' group at the Cochin Institute. His recent research include breakthroughs in newly developed methods for following the migration and activation patterns of lymphocytes and other immune cells within tumors.

Bibliographic information

  • Book Title Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy
  • Editors Emmanuel Donnadieu
  • Series Title Resistance to Targeted Anti-Cancer Therapeutics
  • Series Abbreviated Title Resistance to Targeted Anti-Cancer Therapeutics
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-42221-3
  • Softcover ISBN 978-3-319-82528-1
  • eBook ISBN 978-3-319-42223-7
  • Series ISSN 2196-5501
  • Series E-ISSN 2196-551X
  • Edition Number 1
  • Number of Pages VIII, 199
  • Number of Illustrations 8 b/w illustrations, 19 illustrations in colour
  • Topics Cancer Research
    Molecular Medicine
  • Buy this book on publisher's site
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