Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy

  • Emmanuel Donnadieu

Part of the Resistance to Targeted Anti-Cancer Therapeutics book series (RTACT, volume 9)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Jens V. Stein, Federica Moalli, Markus Ackerknecht
    Pages 1-19
  3. Pierre-Louis Loyher, Christophe Combadière, Alexandre Boissonnas
    Pages 21-49
  4. Kellsye L. Fabian, Walter J. Storkus
    Pages 51-76
  5. Bertrand Dubois, Hélène Kaplon, Coline Couillault, Christophe Caux, Marie-Caroline Dieu-Nosjean
    Pages 99-125
  6. Stefano Garetto, Claudia Sardi, Diego Morone, Marinos Kallikourdis
    Pages 163-177
  7. Back Matter
    Pages 195-199

About this book


This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.

The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.


Cancer Treatment Anti-tumor immune response Immogenic tumors Cancer-associated fibroblasts Cancer-associated Tertiary Lymphoid Structures Cancer immunotherapy Chemokines Chimeric antigen receptor

Editors and affiliations

  • Emmanuel Donnadieu
    • 1
  1. 1.Institut Cochin INSERM, Université Paris DescartesParisFrance

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