Metabolic Engineering for Bioprocess Commercialization

  • Stephen Van Dien

Table of contents

  1. Front Matter
    Pages i-v
  2. Stephen Van Dien
    Pages 1-5
  3. Nicholas J. Morse, Hal S. Alper
    Pages 7-30
  4. Wei Niu, Jiantao Guo, Steve Van Dien
    Pages 31-52
  5. James P. Wynn, Robert Hanchar, Susanne Kleff, David Senyk, Tonya Tiedje
    Pages 101-119
  6. Back Matter
    Pages 121-122

About this book


This volume reviews the current metabolic engineering tools and technologies from a practical point of view, and guides researchers as they overcome challenges at various stages of organism and bioprocess development. Microbes have been engineered to produce a variety of industrial products such as fuels, basic chemicals, fine chemicals, nutritional supplements, and pharmaceutical intermediates, and new tools such as gene synthesis, advanced cloning techniques, ‘omics’ analysis, and mathematical modeling have greatly accelerated the pace of innovation in the field. Written by leading experts in the field from both academia and industry, key topics include synthetic biology, pathway engineering, metabolic flux manipulation, adaptive evolution, and fermentation process scale-up. It is suitable for non-specialists, and is a valuable resource for anyone embarking on the exciting path to harnessing the metabolic potential of microorganisms.


Biobased chemicals Pathway engineering Gene expression engineering Heterologous pathway engineering Leveraging gene synthesis Advanced cloning techniques Machine learning Biobased technology commercialization Biofuels Synthetic biology Metabolic flux manipulation

Editors and affiliations

  • Stephen Van Dien
    • 1
  1. 1.Genomatica, Inc. San DiegoUSA

Bibliographic information

Industry Sectors
Chemical Manufacturing
Health & Hospitals
Consumer Packaged Goods