© 2016

Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract

  • Marnix Jansen
  • Nicholas A. Wright
  • Reviews the pathology of early gastric cancers

  • Explores the stem cell biology in the context of upper gastrointestinal cancers

  • Discusses therapeutic modalities in esophageal squamous cell carcinoma and early esophageal cancer


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 908)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Introduction

    1. Front Matter
      Pages 9-9
    2. Juergen Fink, Bon-Kyoung Koo
      Pages 11-25
    3. James A. Evans, Stuart A. C. McDonald
      Pages 27-40
  3. Cancer Progression in the Distal Esophagus

    1. Front Matter
      Pages 79-79
    2. Anne-Fré Swager, Wouter L. Curvers, Jacques J. Bergman
      Pages 81-98
    3. Myrtle J. van der Wel, Marnix Jansen, Michael Vieth, Sybren L. Meijer
      Pages 137-159
    4. O. J. Old, M. Isabelle, H. Barr
      Pages 161-181
    5. David H. Wang, Rhonda F. Souza
      Pages 183-212
    6. Mark Pusung, Sebastian Zeki, Rebecca Fitzgerald
      Pages 237-263
  4. Cancer Progression in the Stomach

    1. Front Matter
      Pages 291-291
    2. Ichiro Oda, Harushisa Suzuki, Shigetaka Yoshinaga
      Pages 317-330
    3. Shigeki Sekine, Hiroshi Yoshida, Marnix Jansen, Ryoji Kushima
      Pages 331-346

About this book


This book is a comprehensive understanding of the evolution of pre-malignant disease, emphasizing common themes in the field, including stem cell biology and histologic modes of cancer progression between the distal esophagus and stomach. Its sixteen chapters discuss metaplastic tissue change in the upper GI, clonalexpansion of early neoplasia, stem cell dynamics in experimental models, pathology of early esophageal squamous cell carcinoma, therapeutic modalities for esophageal squamous cell carcinoma, pathology of Barrett’s esophagus, screening, early detection and novel diagnostic tools for Barrett's esophagus, clonal evolution of Barrett’s esophagus, endoscopic therapeutic modalities of early esophageal cancer, pathology of early gastric cancer, and experimental models for gastric cancer.

Stem Cells, Pre-neoplasia and Early Cancer of the Upper Gastrointestinal Tract is an integrative text on both the current state of translational research on every cancer development of the upper gastrointestinal tract as well as on novel clinical diagnostic and therapeutic modalities. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike. Springer’s Advances in Experimental Medicine and Biology series presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research.


barrett's esophagus esophageal cancer metastasis stomach cancer upper GI

Editors and affiliations

  • Marnix Jansen
    • 1
  • Nicholas A. Wright
    • 2
  1. 1.UCL Cancer InstituteUniversity College LondonLondonUnited Kingdom
  2. 2.Barts Cancer InstituteBarts and the London School of Medicine and DentistryLondonUnited Kingdom

About the editors

Professor Sir Nicholas Wright’s research is in the field of gastrointestinal stem cells and cancer. He was Professor of Pathology at the Royal Postgraduate Medical School at the Hammersmith Hospital, and then became the Dean of the Royal Postgraduate Medical School before becoming the Deputy Principal of the Imperial College School of Medicine in 1998. Sir Nicholas then served as Warden of Barts and the London, Queen Mary’s School of Medicine and Dentistry from 2001 to 2011. He as served as Group Leader at the Histopathology Unit at Cancer Research UK London Research Institute and was President of the Pathological Society of Great Britain and Ireland and the British Society of Gastroenterology. He was knighted in 2006 for services to medicine. Sir Wright has published over 427 scientific articles and received over 12,939 citations.

Dr. Marnix Jansen is a histopathologist at University College London Hospital (UCLH) and Senior Clinical Fellow at Barts Cancer Institute. He a rising young star in the area of upper GI cancer research and he has published 23 scientific papers and has received over 794 citations.

Bibliographic information

  • Book Title Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract
  • Editors Marnix Jansen
    Nicholas A. Wright
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-41386-0
  • Softcover ISBN 978-3-319-82341-6
  • eBook ISBN 978-3-319-41388-4
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XII, 486
  • Number of Illustrations 0 b/w illustrations, 110 illustrations in colour
  • Topics Cancer Research
    Stem Cells
  • Buy this book on publisher's site
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